摘要
目的:探讨胎盘多肽对子宫肿瘤切除术后患者血清炎症因子变化和免疫功能的影响。方法:收集我院收治的子宫肿瘤切除术后患者57例,根据就诊先后顺序不同分为对照组和实验组,实验组采用胎盘多肽治疗,对照组采用常规治疗。检测两组患者CD3^+、CD4^+、CD8^+、NK细胞、CRP及IL-6水平,并比较两组的临床效果。结果:治疗后,两组患者血清CRP及IL-6水平均低于治疗前,且实验组明显低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者CD3^+、CD4^+、CD4^+/CD8^+、NK细胞均高于治疗前,而CD8^+低于治疗前,差异具有统计学意义(P<0.05);实验组患者治疗后CD3^+、CD4^+、CD4^+/CD8^+、NK细胞显著高于对照组,而CD8^+低于对照组,差异具有统计学意义(P<0.05)。与对照组相比,实验组患者的首次排气和排便时间明显较短,差异具有统计学意义(P<0.05)。结论:胎盘多肽能够明显改善子宫肌瘤切除患者的免疫功能,降低炎症反应,有助于患者术后康复。
Objective： To investigate the effect of placenta polypeptide on the level of of inflammatory factors and immune function in patients after hysterectomy. Methods： 57 patients after hysterectomy from our hospital were selected and divided into the control group and the experiment group by order of medical treatment. The patients in experiment group were treated with placenta polypeptide,while the patients in the control group were treated with conventional method. Then the level of CD3^＋, CD4^＋, CD8^＋, NK cells, CRP and IL-6 was detected and compared in the two groups before and after treatment, and the CD4^＋/CD8^＋was calculated and the first exhaustion and defecation time was compared between the two groups. Results： After treatment, the serum level of CRP and IL-6 was decreased in two groups（P〈0.05）, and compared with the control group, the level of CRP and IL-6 were lower in experiment group（P〈0.05）. After treatment, the level of CD3^＋, CD4^＋and CD4^＋/CD8^＋, NK cell was increased and CD8^＋was decreased in two groups（P〈0.05）, and the level of CD3^＋, CD4^＋and CD4^＋/CD8^＋was higher in experimental group than that of control group with statistical significance（P〈0.05）. Compared with control group, the first exhaustion and defecation time were shorter in experiment group（P〈0.05）. Conclusions： Placenta polypeptide can significantly improve the immune function, reduce the inflammatory reaction and improve the recovery of patients with uterine tumor resection.
出处
《现代生物医学进展》
CAS
2016年第9期1734-1737,共4页
Progress in Modern Biomedicine
基金
河北省科技攻关项目(2005158057)
