摘要
目的:探讨胰岛素样生长因子-Ⅰ(insulin-like growth factor-I,IGF-Ⅰ)、胰岛素样生长因子-Ⅰ受体(insulin-like growth factor-I receptor,IGF-ⅠR)在子宫肌瘤患者中的表达及与雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)的关系。方法:选取2015年3月至2018年3月147例子宫肌瘤患者的临床资料,比较其子宫肌瘤与子宫肌组织的免疫组织化学SABC法检测指标ER、PR、IGF-Ⅰ、IGF-ⅠR,并分析子宫肌瘤患者的IGF-Ⅰ、IGF-ⅠR与ER、PR的关系。结果:子宫肌瘤中ER、PR、IGF-Ⅰ、IGF-ⅠR水平阳性率均高于子宫肌组织(P<0.05)。子宫肌瘤患者IGF-Ⅰ、IGF-ⅠR、ER、PR表达水平均高于子宫肌组织(P<0.05)。子宫肌瘤分泌期IGF-Ⅰ、IGF-ⅠR水平高于增生期(P<0.05),且IGF-Ⅰ与ER、PR呈现正相关。结论:子宫肌瘤患者中IGF-Ⅰ、IGF-ⅠR表达水平与ER、PR关系密切,且IGF-Ⅰ在子宫肌瘤的生长及发展中起到调节作用。
Objective:To investigate the expression of insulin-like growth factor-I(IGF-I),insulin-like growth factor-I receptor(IGF-IR)in the patients with uterine myoma and their relationship with estrogen receptor(ER)and progesterone receptor(PR).Methods:The clinical data of 147 patients with uterine fibroids from March 2015 to March 2018 were selected.ER,PR,IGF-I and IGF-IR were detected by immunohistochemical SABC method.The relationship between IGF-I,IGF-IR and ER and PR in patients with uterine fibroids were analysed.Results:The positive rates of ER,PR,IGF-I and IGF-IR levels in uterine fibroids were higher than those in uterine myometrium(P<0.05).The expression levels of IGF-I,IGF-IR,ER and PR in patients with uterine fibroids were higher than those in uterine myometrium(P<0.05).The level of IGF-I and IGF-IR in the secretory phase of uterine fibroids was higher than that in proliferative phase(P<0.05),and IGF-I was positively correlated with ER and PR.Conclusion:The expression level of IGF-I and IGF-IR is closely related to ER and PR in patients with uterine fibroids,and IGF-I plays a regulatory role in the growth and development of uterine fibroids.
作者
康健明
钟颖芙
KANG Jianming;ZHONG Yingfu(Wuchuan Maternal and Child Health Care Family Planning Service Center in Zhanjiang City,Zhanjiang 524500,China)
出处
《包头医学院学报》
CAS
2019年第3期56-57,共2页
Journal of Baotou Medical College
