摘要
目的探讨宫颈癌患者癌组织中基质金属蛋白酶（MMP）2和MMP-9的表达及临床意义。方法选择我院2008年1月至2013年12月收治的宫颈癌患者57例作为观察组，另选取子宫良性病变并行子宫切除术23例患者的宫颈组织行病理检查并作为对照组。观察宫颈癌患者癌组织中MMP-2和MMP-9的阳性表达，并与对照组进行比较。观察不同临床病理特征的宫颈癌患者癌组织中MMP．2和MMP-9的阳性表达，并对癌组织中MMP-2和MMP-9相关性进行分析。结果观察组患者癌组织MMP-2阳性表达率为73．7％（42／57），对照组患者为21．7％（5／23），两组比较差异有统计学意义（P=0．032）。观察组患者癌组织MMP-9阳性表达率为61．4％（35／57），对照组为26．1％（6／23），两组比较差异有统计学意义（P=0．046）。宫颈癌患者癌组织MMP-2、MMP-9阳性表达在不同的年龄、临床分期、组织学分型、组织分化程度、肿瘤直径比较，差异均无统计学意义（P〉均0．05）；而有淋巴结转移的患者中，MMP-2、MMP-9阳性表达均高于无淋巴结转移的患者（P值分别为0．048、0．031）。癌组织中MMP-2、MMP-9阳性表达呈正相关（r＝0．89，P〈0．05）。结论宫颈癌患者癌组织中MMP-2、MMP-9均有较高的阳性表达，且有淋巴结转移的患者中MMP-2、MMP-9阳性表达均高于无淋巴结转移的患者，表明MMP-2、MMP-9促进宫颈癌的发生、发展，且与宫颈癌的侵袭和转移密切相关。
Objective To sdudy the expression and clinical significance of matrix metalloproteinase-2 （MMP-2） and matrix metalloproteinase-9 （MMP-9） in cervical cancer. Methods Fifty-seven cases patients with cervical cancer who were treated in Hexigten Banner Hospital of Chifeng from January 2008 to December 2013 were selected as the observation group, and 23 patients with uterine benign lesion parallel hysterectomy were diagonosed by pathological diagonosis and selected as the control group. The positive expressions of MMP-2 and MMP-9 were observed and compared between observation group and control group. The correlation of MMP- 2 and MMP-9 with clinical pathological factors were analyzed in cervical cancer patients. Results The positive expression rate of MMP-2 in observation group was 73.7% （42/57）, significantly higher than that in the control group （21.7% （5/23）, P = 0. 032）. The positive expression rate of MMP-9 in observation group was 61. 4% （35/ 57）, significantly higher than that in control group（26. 1% （6/23）,P= 0. 046）. There were no significant differences between the expression of MMP-2, MMP-9 with the patient＇s age, the tumor clinical staging, the pathological type, the degree of differentiation and the diameter of tumor（ P〉0. 05 ）, while the positive expression of MMP-2 and MMP-9 in patients with lymph node metastasis was higher than that in patients without lymph node metastasis（ P= 0. 048,0, 031 ）. There was positive correlation between the expression of MMP-2 and MMP- 9（ r = 0. 89,P〈0. 05）. Conclusion The expression of MMP-2 and MMP-9 in cervical cancer is higher than that in benign lesion,and the positive expression of MMP-2 and MMP-9 in patients with lymph node metastasis is higher than that in patients without lymph node metastasis, which indicate that the expression of MMP-2 and MMP-9 may play an role in the occurrence and development of cervical cancer, and associate with the invasion and metastasis of cervical cancer.
出处
《中国综合临床》
2016年第3期267-269,共3页
Clinical Medicine of China
关键词
宫颈癌
基质金属蛋白酶2
基质金属蛋白酶9
Cervical cancer
Matrix metalloproteinase-2
Matrix metalloproteinase-9
