摘要
目的:比较柴疏四君汤对肝郁证、脾虚证、肝郁脾虚证大鼠脂代谢的影响。方法:分别采用慢性束缚、饮食失节+过度疲劳、慢性束缚+饮食失节+过度疲劳的方法复制肝郁、脾虚、肝郁脾虚模型。于造模第15天,给药组灌胃柴疏四君汤。于第29天测定大鼠血中甘油三酯(TG)、总胆固醇(CHO)、高度密脂蛋白胆固醇(HDL-C)、低度密脂蛋白胆固醇(LDL-C)、游离脂肪酸(FFA)。结果:与正常组比较,肝郁组TG显著降低、FFA显著升高,脾虚组TG降低,CHO、HDL-C和FFA显著升高,肝郁脾虚组TG、CHO、HDL-C和FFA显著升高、LDL-C显著降低,差异均有统计学意义(P<0.05)。给药后,肝郁给药组TG、CHO和HDL-C显著升高,LDL-C、FFA显著降低;脾虚给药组TG显著升高,CHO、LDL-C和FFA显著降低;肝郁脾虚给药组TG、CHO、HDL-C、FFA显著降低,LDL-C显著升高,差异均有统计学意义(P<0.05)。结论:肝郁、脾虚和肝郁脾虚证均存在不同程度的脂代谢紊乱,柴疏四君汤对三证大鼠的脂质代谢均有不同程度的改善作用,与肝郁脾虚证之间具有较高的关联。
Objective： To study the effects of Chaishu Sijun Decoction on the lipid metabolism of syndrome of liver depression, spleen deficiency, stagnation of liver qi and spleen deficiency. Methods： The models of syndrome of liver depression, spleen deficiency, and stagnation of liver qi and spleen deficiency were established by chronic restraint stress, excess fatigue ＋ improper diet and chronic restraint stress ＋ excess fatigue ＋ improper diet, respectively. On the 15 th day, the rats in medication groups were given Chaishu Sijun Decoction. On the 29 th day, the serum metabolism indexes of TG, CHO, HDL-C, LDL-C and FFA were detected. Results： Compared with the normal control group, the level of TG decreased and FFA increased significantly in liver depression group（P〈0.05）; the level of TG decreased and CHO, HDL-C and FFA increased significantly in spleen deficiency group（P〈0.05）; the level of TG, CHO, HDL-C, and FFA increased and LDL-C decreased significantly in stagnation of liver qi and spleen deficiency group（P〈0.05）. After treatment, the level of TG, CHO, HDL-C increased and LDL-C, FFA decreased significantly in liver depression medicated group（P〈0.05）; the level of TG increased and CHO, LDL-C, FFA decreased significantly in spleen deficiency medicated group（P〈0.05）; the level of TG, CHO, HDL-C, FFA decreased and LDL-C increased significantly in stagnation of liver qi and spleen deficiency medicated group（P〈0.05）. Conclusion： There are different degrees of abnormal function of lipid metabolism in the liver depression, spleen deficiency, and stagnation of liver qi and spleen deficiency models. After treated by Chaishu Sijun Decoction, the lipometabolism of liver depression, spleen deficiency, and stagnation of liver qi and spleen deficiency are presented varying degrees of improvement. Chaishu Sijun Decoction has the highest correlation with syndrome of stagnation of liver qi and spleen deficiency.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2016年第4期1221-1225,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.81173193)~~
关键词
肝郁证
脾虚证
肝郁脾虚证
疏肝健脾
柴疏四君汤
脂质代谢
Syndrome of liver depression
Syndrome of spleen deficiency
Syndrome of stagnation of liver qi and spleen deficiency
Invigorating the spleen and dispersing the stagnated liver-energy
Chaishu Sijun Decoction
Lipid metabolism
