摘要
目的对比研究顺铂联合五氟尿嘧啶(PF方案)同步放化疗与单纯放疗辅助治疗术后高危子宫内膜癌的毒性反应和复发,发现盆腔或远处转移病灶.方法选择2011年10月至2013年6月云南省肿瘤医院初治、接受规范分期手术,有高危因素的子宫内膜癌患者43例为研究对象,22例行单纯放射治疗,21例行术后辅助DDP+5-FU同步放化疗治疗,对比2组的毒性反应和复发率.结果同步放化疗组与单纯放疗组3极胃肠道反应率分别为61.90%和31.82%(P<0.05),差异有统计学意义;2组2级以上骨髓抑制率分别为66.67%和18.18%(P<0.01),差异有统计学意义;2组2级以上周围神经毒性反应率分别为33.33%和13.64%(P>0.05).同步放化疗组与单纯放疗组总体复发率分别为4.76%和27.27%(P<0.05),差异有统计学意义.结论同步放化疗3级胃肠道反应率增加,2级以上骨髓抑制率显著增加,周围神经毒性反应率不增加,毒性反应可以耐受,减少2 a总体复发率.
Objective To compare the toxicities and recurrence rate with concomitant chemoradiotherapy（CRT） and radiotherapy（RT） alone after radical surgery for high-risk endometrial cancer. Methods A total of43 patients with high-risk endometrial cancer who received standard surgery treatment from Yunnan Cancer Hospital between Oct. 2011 to Jun. 2014 were selected in this study. CRT was given to 21 patients and RT was given to 22 patients. The toxic reactions and the recurrence rate were compared between two groups. Results In Concurrent chemotherapy and radiotherapy alone group, the incidence of Grade 3 gastrointestinal reaction was 61.90% and31.82% respectively, the difference was statistically significant（P 〈0.05）; the incidence of Grade 2 marrow suppression was 66.67% and 18.18% respectively, the difference was significant（P 〈0.01）; the incidence of Grade 2 neurotoxicity was 33.33% and 13.64%,respectively（P 〉0.05）;the overall recurrence rate was 4.76%and 27.27%, respectively（P〈 0.05）. Conclusion Compared with the simple radiotherapy, after the concurrent chemoradiotherapy, the incidence of Grade 3 gastrointestinal reaction may increase, the incidence of Grade 2 Bone marrow suppression may also increase significantly,while the incidence of peripheral neurotoxicity may not increase,the toxicity is acceptable, and the 2-year recurrence rate may decrease.
出处
《昆明医科大学学报》
CAS
2016年第1期81-84,共4页
Journal of Kunming Medical University
基金
云南省应用基础研究基金资助项目(2011FZ130)
关键词
子宫内膜癌
同步放化疗
放射治疗
Endometrial cancer
Concurrent chemoradiotherapy
Radiotherapy
