摘要
目的探讨子宫内膜癌术后应用激素治疗对早期高危型患者预后的影响。方法选取2013年6月至2014年2月早期高危型子宫内膜癌患者70例,将其随机分为观察组和对照组,每组35例,对照组采取常规治疗,观察加用激素治疗,疗程8个月。比较两组雌激素受体(ER)与孕激素受体(PR)阳性率,同时采用酶联免疫吸附试验(ELISA)分析血清CA125抗原、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平,并比较1年内无瘤生存率。结果观察组ER阳性率(94.3%)、PR阳性率(97.1%)、1年内无瘤生存率(91.4%)均高于对照组(P<0.05);治疗后观察组CA125[(5.35±2.76)U/ml]、TNF-α[(15.31±1.52)ng/L]、IL-6[(3.27±0.52)ng/L]低于对照组(P<0.05)。结论子宫内膜癌术后应用激素治疗可有效改善早期高危型患者CA125、ER、PR水平,提高无瘤生存率,改善预后水平,值得临床推广应用。
Objective To investigate the effects of hormone therapy after endometrial carcinoma operation on the prognosis of high risk patients in early-stage. Methods From June 2013 to February 2014,70 patients with high risk endometrial carcinoma in early-stage were selected,and randomly divided into the observation group and the control group,with 35 cases in each group.The control group received ordinary treatment,and the observation group added hormone therapy on the basis of the above,they all treated for 8 months. The positive rate of estrogen receptor（ ER） and progesterone receptor（ PR） in the two groups were compared,enzyme linked immunosorbent assay（ ELISA） was used to analyze serum CA125 antigen,tumor necrosis factor-α（ TNF-α） and interleukin-6（ IL-6） level,the disease free survival in 1 year were compared. Results Positive rate of ER（ 94. 3%）,positive rate of PR（ 97. 1%）,disease free survival in 1 year（ 91. 4%） in the observation group were significantly higher than those in the control group（ P〈0. 05）; after the treatment,CA125[（ 5. 35 ± 2. 76） U / ml],TNF-α[（ 15. 31 ± 1. 52） ng / L],IL-6 [（ 3. 27 ± 0. 52） ng / L] in the observation group were significantly lower than that in the control group（ P〈0. 05）.Conclusion Hormone therapy after endometrial carcinoma operation can improve CA125,ER and PR of high risk patients in early-stage effectively,improve disease free survival and prognosis,has clinic application value.
出处
《临床医学》
CAS
2016年第11期30-31,共2页
Clinical Medicine
关键词
子宫内膜癌
激素治疗
无瘤生存
Endometrial carcinoma
Hormone therapy
Disease-free survival
