摘要
目的探讨麝香保心丸联合卡维地洛治疗缺血性心脏病心力衰竭的临床疗效。方法选取2015年1月—2015年6月上海市闵行区龙柏社区卫生服务中心收治的缺血性心脏病心力衰竭患者300例,随机分为对照组和治疗组,每组各150例。对照组患者在对症治疗的基础上口服卡维地洛片,初始剂量为5 mg/次,2次/d,5 d后以5 mg/d递增,总量不超过50 mg/d。治疗组患者在对照组的基础上口服麝香保心丸,2粒/次,3次/d。两组均连续治疗3个月。观察两组的临床疗效,同时比较治疗前后两组心率(HR)、心排血量(CO)、左心室射血分数(LVEF)、左室舒张末期内径(LVEDD)及收缩末期内径(LVESD)的变化情况。结果治疗后,对照组和治疗组的总有效率分别为74.0%、87.3%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者HR、LVEDD、LVESD均显著降低,CO、LVEF显著升高,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论麝香保心丸联合卡维地洛治疗缺血性心脏病心力衰竭具有良好的疗效,能够明显改善患者心功能,且安全性较高,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of Shexiang Baoxin Pills combined with carvedilol in treatment of heart failure caused by ischemic heart disease. Methods Patients（300 cases） with heart failure caused by ischemic heart disease in Longbai Community Health Service Center of Minhang District in Shanghai from January 2015 to June 2015 were randomly divided into control（n = 150） and treatment（n = 150） groups. The patients in the control group were po administered with Carvedilol Tablets on the basis of symptomatic treatment, and the initial dosage was 5 mg/time, twice daily. After 5 days, the dosage was increased with 5 mg/d, and the total dosage was not exceed 50 mg/d. The patients in the treatment group were po administered with Shexiang Baoxin Pills on the basis of the control group, 2 grains/time, three times daily. The patients in two groups were treated for 3 months. After treatment, the efficacy was evaluated, and the changes of HR, CO, LVEF, LVEDD, and LVESD in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 74.0% and 87.3%, respectively, and there were differences between two groups（P〈0.05）. After treatment, HR, LVEDD, and LVESD in two groups were significantly decreased, and CO and LVEF were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Shexiang Baoxin Pills combined with carvedilol has clinical curative effect in treatment of heart failure caused by ischemic heart disease, and can significantly improve cardiac function with higher security, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2016年第3期294-297,共4页
Drugs & Clinic
关键词
麝香保心丸
卡维地洛片
心力衰竭
缺血性心脏病
Shexiang Baoxin Pills
Carvedilol Tablets
heart failure
ischemic heart disease
