摘要
目的分析无细胞百白破疫苗（DTa P）接种后疑似预防接种异常反应（adverse event following immunization,AEFI）主动监测和被动监测结果,评价主动监测模式的敏感性。方法通过全国AEFI信息管理系统,收集北京市朝阳区2010~2013年4~6月DTa P AEFI被动监测个案数据;2013年4~6月对朝阳区4家试点社区接种DTa P的儿童实施主动监测,收集AEFI个案数据;比较试点社区AEFI主动监测与同期自身被动监测、同期对照社区被动监测、自身历年被动监测、历年朝阳区被动监测的情况。结果主动监测AEFI报告率为8 561.24/10万,高于同期自身被动监测、同期对照社区被动监测、自身历年被动监测、历年朝阳区被动监测报告率,差异均有统计学意义（P均〈0.001）;主动监测一般反应报告率为7 491.08/10万,异常反应报告率为118.91/10万,偶合症报告率为951.25/10万,均高于被动监测,差异均有统计学意义（P均〈0.01）。结论 AEFI主动监测敏感性好,与被动监测相比,更能客观、真实、完整地反映疫苗接种后AEFI信息。
Objective To compare the results of passive and active surveillances on adverse events following immunization（AEFI） of DTa P vaccine and evaluate the sensitivity of active surveillance model. Methods The data on passive surveillance of AEFI of DTa P in Chaoyang District of Beijing City from April to June of 2010 ~ 2013 were collected through the national AEFI information management system. Active surveillance was performed on children vaccinated with DTa P in four pilot communities in Chaoyang District from April to June 2013, of which the data on AEFI were collected. The situations of active and passive surveillances on AEFI in trial communities in the same period, the passive surveillance in control communities in the corresponding period, the passive surveillances in trial communities over the years as well as the passive surveillances in Chaoyang District over the years were compared. Results The report rate of AEFI in active surveillance in trial communities was 8 561. 24 / 100 000, which was significantly higher than those in passive surveillance in the same period, the passive surveillance in control communities in the corresponding period, the passive surveillance in trial communities over the years and the passive surveillances in Chaoyang District over the years（each P 〈0. 001）. The report rates of general reactions, abnormal reactions and coupling diseases in active surveillances were 7 491. 08 / 100 000, 118. 91 / 100 000 and 951. 25 / 100 000 respectively, which were significantly higher than those in passive surveillances（each P 〈0. 01）. Conclusion The active surveillance on AEFI showed high sensitivity, which reflected the information on AEFI more objectively, actually and comprehensively as compared with passive surveillance.
出处
《中国生物制品学杂志》
CAS
CSCD
2016年第3期288-291,共4页
Chinese Journal of Biologicals
关键词
疑似预防接种异常反应
主动监测
被动监测
无细胞白百破疫苗
Suspected adverse events following immunization
Active surveillance
Passive surveillance
Diphtheria
tetanus and acellular pertussis combined vaccine（DTaP）
