摘要
目的:探讨高迁移率组蛋白1(HMGB1)和基质金属蛋白酶-9(MMP-9)m RNA在子宫内膜癌中的表达水平和临床意义。方法:应用RT-PCR法检测正常子宫、单纯性增生症、非典型增生症和子宫内膜癌子宫内膜组织HMGB1和MMP9 m RNA的表达水平。结果:子宫内膜癌组织HMGB1、MMP-9 m RNA的表达量明显高于正常子宫、单纯性增生症、非典型增生症子宫内膜组织(P<0.05);子宫内膜癌组织HMGB1、MMP-9m RNA的表达均与FIGO分期、淋巴结转移和浸润深度有关(P<0.05)。结论:HMGB1、MMP-9在子宫内膜癌的发生、发展和转移过程中可能起着重要作用。
Objective： To investigate the expression and clinical significance of high-mobility group box 1 protein （HMGB1） and matrix metalloproteinases-9 （MMP-9） mRNA in endometrial carcinoma. Methods： RT-PCR was used to detect the HMGB1 and MMP-9 mRNA expression level in normal endometrial tissue, endometrial hyperplasia, atypical endometrial hyperplasia and endometrial carcinoma. Results： The HMGB 1 and MMP-9 mRNA expression level in endometrial carcinoma were obviously higher than normal endometrial tissue, endometrial hyperplasia and atypical endometrial hyperplasia （P〈 0.05）. In endometrial carcinoma, the expression of HMGB1 and MMP-9 were all related to FIGO stage, lymph node metastasis and infiltration depth （P〈 0.05）. Conclusions： HMGB1 and MMP-9 may play important role in genesis, development and metastasis of endometrial carcinoma.
出处
《承德医学院学报》
2016年第2期97-99,共3页
Journal of Chengde Medical University
基金
河北省科技厅项目(14277766D)
