摘要
目的探究高迁移率族蛋白B1(HMGB1)在Ⅰ型及Ⅱ型子宫内膜癌中的表达及临床意义。方法选取我院2015年1月-2018年12月期间接收的子宫内膜癌患者100例,根据病理分型分为Ⅰ型组(50例)和Ⅱ型组(50例),对比2组HMGB1阳性率。结果Ⅱ型组HMGB1阳性细胞率高于Ⅰ型组,差异有统计学意义(P<0.05)。结论在子宫内膜癌患者中HMGB1表达异常,对其病理分型具有一定的鉴别价值,临床上需要加以重视。
Objective To investigate the expression and clinical significance of high mobility group protein B1(HMGB1)in typeⅠand typeⅡendometrial carcinoma.Methods 100 patients with endometrial cancer received from January 2015 to December 2018 in our hospital were selected.According to the case classification,they were divided intoⅠgroup(50 cases)and typeⅡgroup(50 cases).The expression of HMGB1 was detected by immunohistochemistry in both groups,and the positive rate of HMGB1 was compared between the two groups.Results The incidence of HMGB1 positive cells in typeⅡgroup was higher than that in typeⅠgroup,and the difference was statistically significant(P<0.05).Conclusion There is a certain abnormality in the expression of HMGB1 in the formation of endometrial cancer.Ⅰt has certain application value for the diagnosis of case classification,and it needs to be paid attention to in clinical.
作者
华金仁
曾丹
潘玫
Hua Jinren;Zeng Dan;Pan Mei(The Jiangxi Province Maternal and Child Health Hospital,Nanchang,Jiangxi 330006)
出处
《基层医学论坛》
2020年第4期448-450,共3页
The Medical Forum
基金
江西省卫生计生委科技计划(20175428)
关键词
子宫内膜癌
HMGB1
表达
临床意义
病理分型
Endometrial cancer
HMGB
Expression
Clinical significance
Pathological classification
