摘要
目的研究肺炎支原体(MP)感染儿童急性期血清单核细胞趋化蛋白-1(MCP-1)与白细胞介素-10(IL-10)水平,探讨其临床意义。方法将160例研究对象分为3组:MP肺炎组(A组,80例)、非MP肺炎组(B组,40例)和对照组(C组,40例)。A组按照重症支原体肺炎诊断标准,分成普通型组(52例)和重症组(28例);普通型组按有无蛋白尿分成蛋白尿组(30例)和无蛋白尿组(22例)。采用ELISA法检测MCP-l与IL-10水平。结果 1 A组MCP-1、IL-10水平均高于B组和C组(P<0.05);2重症组MCP-1水平明显高于普通型组(t=9.9031,P<0.05);3蛋白尿组与无蛋白尿组MCP-1水平差异无统计学意义(t=0.0605,P>0.05)。结论 MP肺炎患儿血清MCP-1及IL-10水平均显著升高,且与其他原因所致肺炎差异明显,提示血清MCP-1及IL-10水平可作为早期诊断MP肺炎的依据之一。
Objective To investigate the levels of serum MCP-1 and IL-IO in children with Mycoplasma pneumoniae and their clinical significance. Methods The current study included 160 subjects which were divided into three groups： the mycoplasmal pneumonia （the group A）, the non-mycoplasmal pneumonia group （the group B） and the normal group （ the group C）. According to the diagnostic criteria of severe mycoplasmal pneumonia, the chil- dren in the mycoplasmal pneumonia group were further divided into two groups： the popular type group （52 cases） and the severe group （28 cases） in which the former ones were divided into the proteinuria group （30 cases） and the without-proteinuria group （22 cases）. The blood samples of each group were harvested and double？ antibody sand- wich ELISA was used to detect the levels of serumal MCP-1 and IL-10. Results The levels of serum MCP-1 in the group A was higher than in the group B and C （ P 〈 0. 05）. In addition, among the mycoplasmal pneumonia group, severe children had higher MCP-1 （ t = 9. 9025, P 〈 0. 05）. Compare with the children with or without proteinuria, there was no statistical difference （t = 0. 0608, P 〉 0.05 ）, which illustrated no obvious relevance between proteinuri- a and MCP-1 level. The levels of serum IL-10 in the group A were higher than the other two groups （ P 〈 0.05 ）, which also showed a higher level of IL-10 in mycoplasmal pneumonia children. Conclusion The levels of serum IL- 10 in the mycoplasmal pneumonia group are higher than the other two groups, which also shows a higher level of IL-10 in mycoplasmal pneumonia children.
出处
《临床肺科杂志》
2016年第4期656-659,共4页
Journal of Clinical Pulmonary Medicine
基金
深圳市龙华新区区级课题(No 20140917A1030033)
