摘要
目的探讨不同临床表现的肺炎支原体(MP)肺炎患儿血浆IL-6、8和18水平变化的意义。方法根据患儿发热和肺部炎症转归时间,分为普通组(21例)和迁延组(8例);利用酶联免疫吸附试验检测MP肺炎患儿和对照组(10例)儿童血浆IL-6、8和18水平,并进行统计学比较。结果MP肺炎急性期普通组和迁延组血浆IL-6、8和18水平均明显升高,与对照组比较差异均有显著性(P均<0.05);恢复期普通组和迁延组血浆IL-6和IL-8水平下降,与对照组比较无显著意义(P>0.05);但迁延组IL-18水平恢复期虽有下降,但仍较对照组高,且差异具有显著意义(P<0.05),而普通组IL-18水平则恢复正常,与对照组比较差异无显著性(P>0.05)。结论IL-6、8和18均可能参与MP肺炎的发病机制;IL-18可能与疾病迁延有关,且迁延型MP肺炎可能为自身免疫性疾病。
Objective To investigate the changes of interleukin（IL） - 6, IL- 8 and IL- 18 in children with different clinical manifestations due to myeoplasrna pneumoniae（MP） pneumonia. Methotls The children with MP peumonia were divided into general group （21 cases） and late group （8 cases） according to the time of fever- lasting and pulmonary infection - lasting. The levels of IL- 6, IL - 8 and IL- 18 were measured by enzyme linked immunosorbent assay ,along with being compared in children with MP pneumonia. Results In acute term, the levels of IL - 6, IL- 8 and IL- 18 in children with MP pneumonia were significantly higher than those in control group（all P〈0.05）. However, the levels of IL - 6 and IL - 8 in convalescence almost recoverd in general group and late group, but the level of IL - 18 in late group was still higher than that in control group（P 〈 0.05）. Conchtsions IL - 6, IL - 8 and IL - 18 may all play some role in the pathogenesis of MP pneumonia. Perhaps, IL- 18 can be associated with late MP pneumonia, which may be an autoimmune disease.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2006年第16期1062-1063,共2页
Journal of Applied Clinical Pediatrics
基金
吉林省发改委项目资助(2005-1564)
关键词
肺炎支原体
肺炎
白细胞介素
myeoplasrna pneumoniae
pneumonia
interleukin
