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单核细胞趋化蛋白1与妇科肿瘤 被引量：3

MCP-1 and Gynecological Tumor
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摘要 单核细胞趋化蛋白1(MCP-1)作为单核细胞的特异性趋化和激活信号分子,多项研究表明,其为肿瘤内巨噬细胞浸润量的决定因素。MCP-1诱导巨噬细胞瘤内浸润,有抑瘤和促瘤的双向作用。MCP-1在妇科肿瘤中也有相似的作用。本文就MCP-1在妇科肿瘤中的作用予以综述。 Monocyte chemoattractant protein（ MCP-1 ）is a special signaling molecule for the special tendency and activation of mononuclear cells. Many researches indicated that it is the determinative factor of quantity of macrophage invasion in tumor. MCP-1 induced macrophages to infiltrate in tumors, and has dual effect of promoting tumor and inhibiting tumor. MCP-1 has similar effect in gynecological tumors. This article reiews the effect of MCP-1 in gynecological tumors.
作者 李彩霞 孔祥
机构地区 扬州大学医学院第一附属医院江苏省苏北人民医院妇科
出处 《医学综述》 2008年第16期2444-2447,共4页 Medical Recapitulate
关键词 单核细胞趋化蛋白1 肿瘤 妇科肿瘤 monocyte chemoattractant protein-1 Tumor Gynecological tumor
分类号 R737.3 [医药卫生—肿瘤]
  • 相关文献

参考文献24

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二级参考文献25

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  • 2Boekhoudt GH,Guo Z,Beresford GW,et al.Communication between NF-kappa B and Sp1 controls histone acetylation within the proximal promoter of the monocyte chemoattractant protein 1 gene.J Immunol,2003,170(8),4139～4147 被引量：1
  • 3Finzer P,Soto U,Delius H,et al.Differential transcriptional regulation of the monocytechemoattractant protein-1(MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells:the role of the chromatin structure and AP-1 composition.Oncogene,2000,19(29),3235～3244 被引量：1
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共引文献10

同被引文献18

  • 1张瑞,王选.大鼠急性胰腺炎中核因子NF-κB抗凋亡机制的研究[J].中国现代医学杂志,2005,15(24):3740-3742. 被引量：2
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  • 9Panicker SR, Kartha CC. Curcumin attenuates Glucose- Induced monocyte chemoattractant protein-1 synthesis in aortic endothelial cells by modulating the nuclear factor- kappa B pathway[J]. Pharmacology, 2010,85 (1): 18-26. 被引量：1
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引证文献3

二级引证文献16

医学综述
2008年 第16期

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