摘要
上皮间质转化(EMT)是肿瘤侵袭和转移的关键环节。转录因子SNAIL、TWIST和ZEB在EMT中作用研究较多。它们转录调控EMT相关分子标志物的表达。同时,它们受表观遗传学、转录水平和转录后水平复杂而精准的调控。阐明转录因子调控EMT在肿瘤侵袭和转移中的分子生物学机制,将为肿瘤侵袭和转移的靶向治疗和药物研发提供新思路。
Epithelial-mesenchymal transition（ EMT） is regarded as a key step in cancer invasion and metastasis.Transcriptional factors（ TFs） are primary clues in initiating EMT,such as SNAIL,TWIST and ZEB. TFs modulate transcription of EMT-associated genes. Meanwhile,they also experienced epigenetic reprogramming and transcriptional and post-transcriptional regulation. Elucidation the molecular mechanisms of TF-driven EMT in cancer invasion and metastasis would provide new insights in target therapy and drug design.
出处
《基础医学与临床》
CSCD
2016年第2期272-276,共5页
Basic and Clinical Medicine
基金
湖北省自然科学基金(2014CFC1154)
关键词
转录因子
上皮间质化
肿瘤
侵袭
转移
transcriptional factor
epithelial-mesenchymal transition
cancer
invasion
metastasis
