摘要
肿瘤细胞向远处转移受多因素调控,涉及多个基因,需要经历一系列连续的、可选择的级联事件。上皮间质转化(Epithelial-mesenchymal transition,EMT)是肿瘤细胞转移中的关键步骤,但肿瘤发生EMT的机制至今尚不完全明确。微RNA(MicroRNA,miRNA)是一类内源性、非编码小分子RNA,可在转录后水平负调控EMT相关基因的表达,在肿瘤转移中发挥重要作用。文章主要就EMT与肿瘤转移的关系、影响EMT的转录因子,以及miRNA通过靶向EMT相关的转录因子影响肿瘤转移等方面进行了综述。
Distant metastasis of tumor cell is a series of continuous, selectable cascades of events regulated by multiple factors and genes. Epithelial-mesenchymal transition （EMT） is a critical step during cancer metastasis. However, the me- chanism of EMT in tumor is not yet fully elucidated. MicroRNAs （miRNAs） are a class of non-coding small endogenous RNAs that negatively regulate EMT-related genes at the post-transcriptional level and play critical roles in cancer metastasis This review mainly focuses on the topics that include the relationship of EMT and tumor metastasis, transcription factors involved in EMT, and the effect of miRNAs on tumor metastasis by targeting the EMT-related transcription factors.
出处
《遗传》
CAS
CSCD
北大核心
2014年第7期637-645,共9页
Hereditas（Beijing)
基金
浙江省高等学校中青年学科带头人学术攀登项目(编号:pd2013103)
浙江省科技厅公益技术应用研究项目(编号:2013C37029)
宁波市科技创新团队项目(编号:2011B82014)
宁波大学创优秀硕士论文培育基金项目(编号:PY2012010)
宁波大学王宽诚教育基金资助
关键词
微RNA
肿瘤转移
上皮间质转化
microRNAs
tumor metastasis
epithelial-mesenchymal transition
