摘要
目的探讨哮喘和慢阻肺重叠综合症(ACOS)患者中血D-二聚体、纤维蛋白原的临床变化情况。方法选取ACOS患者(ACOS组)40例,单纯慢性阻塞性肺疾病患者(单纯慢阻肺阻)40例,健康体检者(健康体检组)40例,测定各组血D-二聚体、纤维蛋白原含量,进行统计学比较分析。结果 ACOS组患者血D-二聚体及纤维蛋白原含量分别为(3.93±3.96)μg/ml、(6.26±2.24)g/L,明显高于单纯慢阻肺组的(2.25±0.94)μg/ml、(5.42±0.95)g/L,差异有统计学意义(P<0.05);而ACOS组和单纯慢阻肺组患者的血D-二聚体及纤维蛋白原含量均高于健康体检者,差异均有显著统计学意义(P<0.01)。结论 ACOS患者较单纯慢阻塞性肺疾病患者存在更明显的血栓前状态,血D-二聚体、纤维蛋白原可以评估ACOS患者发生血栓性疾病的危险性及判断预后。
Objective To investigate the c1inica1 changes of serum D-dimer,fibrinogen for the patients with asthma and copd over1ap syndrome（ACOS）. Methods Forty patients with ACOS,40 patients with COPD were random1y se1ected. The serum D-dimer,fibrino-gen 1eve1s of the two groups were determined which compared with 40 hea1thy persons. Results The serum D-dimer,fibrinogen 1eve1s in ACOS,COPD groups were higher than the hea1thy group（P 〈 0. 01）. The ACOS 1eve1 was higher than the COPD 1eve1（P 〈 0. 05）. Conclusion The prothrombotic state obvious1y exists in ACOS than in COPD. The 1eve1 of serum D-dimer,fibrinogen in ACOS can detect thrombotic diseases and eva1uate the prognosis.
出处
《临床军医杂志》
CAS
2015年第12期1230-1232,共3页
Clinical Journal of Medical Officers
