摘要
目的:优化雪松松针中总木脂素的提取工艺。方法:以乙醇体积分数、液料比、提取时间为响应因子,总木脂素含量为响应值,采用基于Box-Behnken设计的响应面法优化雪松松针中总木脂素的提取工艺。结果:优化的提取工艺为乙醇体积分数78%、液料比25∶1、提取时间1.75 h。在此工艺条件下提取得到的总木脂素含量为99.2 mg/g,与理论预测值100.49 mg/g接近,相对偏差为0.65%。结论:利用响应面法优化得到的雪松松针中总木脂素的提取工艺稳定可行,且具有较好的预测性。
OBJECTIVE： To optimize the extraction technology of total lignans from pine needles of Cedrus deodara. METHODS： Using ethanol volume fraction, ratio of liquid to solid and extraction time as response factor, the content of total lignans as response value, the response surface methodology test was conducted based on Box-Behnken design to optimize the extraction technology of total lignans from pine needles of C. deodara. RESULTS： The optimal extraction technology was as follows as ethanol volume fraction of 78%, ratio of liquid to solid 25 ： 1, extraction time 1.75 h. The content of total lignans from pine needles of C. deodara was 99.2 rag/g, which was close to predicted value 100.49 mg/g, with relative deviation of 0.65%. CONCLUSIONS： Optimized extraction technology of pine needles of C. deodara by response surface methodology is feasible and stable, and has good predictability.
出处
《中国药房》
CAS
北大核心
2016年第7期939-942,共4页
China Pharmacy
基金
甘肃省科技支撑计划项目(No.1204FKCA152)
兰州市人才创新创业项目(No.2014-RC-62)
关键词
雪松松针
总木脂素
提取工艺
BOX-BEHNKEN设计
响应面法
Pine needles of Cedrus deodara
Total lignans
Extraction technology
Box-Behnken design
Response surfacemethodology
