摘要
目的:观察右美托咪定(DEX)对成年全身麻醉手术患者脑电波频段功率百分比的影响。方法:12名择期全麻手术患者给予1.0μg/kg·h DEX泵注,10 min后降低剂量(0.5μg/kg·h)维持泵注,用Narcotrend麻醉深度监测仪监测给药前和给药后达到常规镇静NI值时对应的4种脑电波(α、β、θ、δ)功率百分比;同时采用警觉镇静评分(OAA/S)评价其镇静深度,观察给药前后患者心率(HR)、收缩压(SBP)、舒张压(DBP)及脉搏氧饱和度(Sp O2)的变化。结果:与给药前比较,12例全麻手术患者给DEX后SBP和DBP下降、HR减慢(P<0.05),NI值明显降低(P<0.05),脑电δ波功率百分比明显下降(P<0.05),脑电α、β、θ波功率百分比升高(P<0.05)。结论:DEX达到常规镇静时,4种脑电波频段功率百分比均有明显改变,DEX"易唤醒"的镇静特性可能与这些脑电波改变有关。
Objective： To investigate the effect of dexmedetomidine on EEG power spectrum percentage in adult patients underwent general anesthesia. Methods： Twelve general anesthesia patients were given 1.0 μg/kg dexmedetomidine for 10 minutes, then maintained with 0.5 μg/（ kg· h）, the depth of sedation and the EEG spectrum power percentage （α, β, θ, δ） of the patients were monitored by Narcotrend monitor. OAA/S score was also adopted to assess the sedation. The changes of HR, SBP, DBP and SpO2 were recorded at the same time. Results： Twelve patients systolic pressure, diastolic pressure and heart rate decreased （ P 〈 0.05 ） after medication ; NI value decreased significantly （ P 〈 0.05 ）, brain wave δ power percentage decreased significantly （ P 〈 0.05）, brain wave α, β, θ power percentage increased（P 〈 0.05 ）. Conclusion： Obvious changes had found after medication in EEG power spectrum percentage; and its ＂easy to wake up＂ has a potential relationship with the changes of EEG power spectrum.
出处
《贵阳医学院学报》
CAS
2016年第2期225-227,共3页
Journal of Guiyang Medical College
关键词
右美托咪定
麻醉
全身
镇静
脑电波
dexmedetomidine
anesthesia, general
sedation
electroencephalogram
