摘要
背景:定量药物脑电图可反映大脑皮质功能,全麻药物对脑皮质功能有肯定影响,由于麻醉深度与麻醉剂量有很好的相关性,若能找出与麻醉药剂量相关性好的定量药物脑电图的脑区与频段,则此频段可能成为反映麻醉深度的指标。目的:观察异丙酚对家兔定量药物脑电图α2频段的影响。设计:随机对照动物实验。单位:徐州医学院江苏省麻醉学重点实验室。材料:实验在徐州医学院动物实验室进行。取健康成年白兔36只,随机均分为异丙酚2.5,5,10mg/kg3组,每组12只,其中6只用于观察定量药物脑电图各频段功率百分比变化,另外6只用于观察兔翻正反射消失的潜伏期和持续期。方法:每日14:00～17:00进行实验。3组兔分别静脉注射异丙酚2.5,5,10mg/kg,药物均在30s内匀速注完。①将清醒兔俯卧位固定在兔台上,采用功率谱分析法,分别记录3组兔给药前和给药后20,30,40,50,60,70,80,90,100,110s,2,5,10,15,20,30min的定量药物脑电图。每时间点采样时间为5s。②记录兔翻正反射消失的潜伏期和持续期。结果:36只兔全部进入结果分析。①兔静脉注射异丙酚后,翻正反射均在1min内消失。剂量越大,潜伏期越短,持续期越长(r=0.79,P<0.01)。②与给药前相比,异丙酚2.5mg/kg对α2频段的功率百分比无明显影响(P>0.05);5mg/kg时,各脑区α2频段的功率百分比在给药后升高(P<0.05);10mg/kg时,除左右顶区与2.5mg/kg组差异无显著性外,各脑区α2频段的功率百分比较给药前及前两个剂量组均下降(P<0.05),以上变化以额、颞区最为明显。结论:异丙酚对兔定量药物脑电图α2频段的功率百分比的影响呈双向型,提示α2频段可能成为反映异丙酚麻醉深度的指标。
BACKGROUND： Quantitative pharmaco-electroencephalography （QPEEG） can reflect cerebral cortical function, which can be certainly affected by general anesthetics. Anesthesia depth has good correlation with the anesthetic dosage, so if we can find out the areas of brain and band of QPEEG which is relative to the anesthetic dosage, the band may be taken as the index to reflect the depth of anesthesia.
OBJECTIVE： To observe the effects of propofolon the alpha2-band （α2- band） of QPEEG in rabbits. DESIGN： A randomized control animal experiment.
SETTING： Jiangsu Provincial Key Laboratory of Anesthesiology, Xuzhou Medical College.
MATERIALS： The experiment was carried out in the animal laboratory of Xuzhou Medical College from October 2004 to August 2005. Thirtysix healthy adult rabbits were randomly divided into propofol2.5, 5 and 10 mg/kg groups with 12 rabbits in each,, including 6 were used to observe the change of percentage of each band power of QPEEG, and the other 6 were used to observe the latency and duration for the disappearance of righting reflex in the rabbits.
METHODS： The experiment was performed between 14：00-17：00 every day. Rabbits in the three groups were treated with intravenous injection of propofol of 2.5, 5 and 10 mg/kg respectively within 30 seconds. ① The conscious rabbits were fixed onto the platform in a prone position, and the QPEEG was recorded with the method of power spectrum analysis before administration and at 20, 30, 40, 50, 60, 70, 80, 90, 100 and 110 s and 2, 5, 10, 15, 20 and 30 minutes after administration respectively. The sampling time for each time point was 5 s. ② The latency and duration for the disappearance of righting reflex in the rabbits were recorded.
RESULTS： All the 36 rabbits were involved in the analysis of results. ① After the intravenous injection of propofol, the righting reflexes all disappeared within 1 minute. The greater the dosage, the shorter the latency and the longer the duration （r=0.79, P 〈 0.01）. ② Comp
出处
《中国临床康复》
CSCD
北大核心
2006年第30期187-189,共3页
Chinese Journal of Clinical Rehabilitation
基金
国家自然科学基金资助项目(30471657,39970715)
江苏省科委社会发展研究计划项目(BS2000052)
江苏省自然科学基金资助项目(BK2001143)~~
