摘要
目的了解母体乙型肝炎病毒五项指标定量检测状况对婴儿乙型肝炎病毒免疫力和易感性的影响。方法收集2013年1月～2014年12月间在我院住院婴儿及其母亲分娩前均进行乙型肝炎病毒五项指标定量检测的病例,并对检测结果进行统计学分析。结果 467例产妇中HBs Ag阳性17例,阳性率3.64%。467例婴儿中HBs Ag全部阴性。乙型肝炎病毒表面抗体定量检测不同浓度组比较各组婴儿抗体浓度均高于母体,差异有高度统计学意义（P〈0.01）。婴儿不同年龄乙型肝炎病毒表面抗体定量检测只有新生儿出生≤7 d组母婴抗体存在明显差异（P〈0.01）。乙型肝炎病毒e抗体各组婴儿抗体浓度均低于母体,各组差异均有高度统计学意义（P〈0.01）。乙型肝炎病毒核心抗体母婴配对比较表明：抗体浓度≤3 NCU/m L,抗体浓度差异无统计学意义;而抗体浓度〉3 NCU/m L,差异有统计学意义（P〈0.05）。结论 （1）乙型肝炎病毒宫内感染的机率很低。（2）乙型肝炎病毒表面抗体可通过胎盘逆浓度梯度主动转运,母体抗体浓度越低,这种转运的效能越高。（3）非保护性乙型肝炎病毒e抗体母体胎儿间可认为是一种被动转运,而乙型肝炎病毒核心抗体在低浓度时可能存在主动转运,高浓度时则是被动转运。
Objective To quantify the influence of maternal five HBV indexes on the infants‘immunity and susceptibility to HBV. Methods The cases to quantify the five HBV indexes of the mother before delivery and infants in the first people＇s hospital of Nanyang from January 1, 2013 to December 31, 2014 were collected and statistically analyzed.Results Among 467 maternal cases, 17 were HBs Ag positive with 3.64% rate, whereas infants were HBs Ag negative.The concentrations of infants Hepatitis B virus surface antibody were higher than the mother in all of the groups with different concentration, P0.01 which means the difference was significant. When cases were grouped based on infant＇s age, only the infants with less than 7 days showed a significant difference in the Anti-HBs concentration among the mothers and infants（P〈0.01）. The concentrations of Antibody to Hepatitis B virus e antigen were lower than the mother in all of the groups with the significant difference at and the uprate of Anti-HBe was negative（P〈0.01）. The pairwise comparison of antibody to Hepatitis B virus core antigen concentration of mother and infants showed that when the antibody concentration was less than or equal to 3 NCU/m L, There was no statistically significant difference; Otherwise,the antibody concentration3 NCU/m L, which means the difference was statistically significant when the antibody concentration was more than 3 NCU/m L（P〈0.05）. Conclusion（1）The risk of intrauterine infection of Hepatitis B virus is very low.（2）HBs Ag can transfer actively through the placenta against a concentration gradient,maternal antibody concentration is lower, the transfer sufficiency is higher.（3） It can be thought that the transport of HBe Ab between the mother and the infant in a passive manner, and Anti-HBc may transport actively when the antibody concentration is low, conversely, it transfer in a passive manner.
出处
《中国现代医生》
2016年第2期79-81,共3页
China Modern Doctor
关键词
乙型肝炎病毒五项指标
定量检测
抗体浓度
母婴
Hepatitis B virus five indexes
Quantitative detection
Qntibody concentration
Maternal and infant
