摘要
目的探讨妊娠合并慢性乙型肝炎患者乙肝五项定量与HBV-DNA的相关性以及对病情判断的临床诊断价值.方法选择2010年1月至2013年1月妇产科收治的妊娠合并慢性乙型肝炎患者382例作为观察组,同期健康的正常妊娠女性80例作为对照组.两组患者均于入选后次日晨检测血清乙肝五项定量及HBV-DNA水平,并对两者的相关性做出评估.结果将2组孕妇乙肝五项检测结果分成8种模式,HBsAg、HBeAg、HBcAb阳性者及HBsAg、HBeAg阳性患者具有较高的HBV-DNA检出率并且具有较高的HBV-DNA水平,对照组孕妇乙肝五项检测及HBV-DNA水平均未见异常.HBV-DNA阳性组HBsAg、HBeAg、HBcAb较HBV-DNA阴性组存在显著性差异(P<0.05),HBsAb、HBeAb较对照组存在极显著性差异(P<0.01).HBsAb、HBeAb与HBV-DNA定量之间呈显著负相关(P<0.05),HBsAg、HBeAg、HBcAb与HBV-DNA呈显著正相关(P<0.05).结论乙肝五项定量和HBV-DNA检测具有较好的相关性,两者同时检测可较好的反映该类患者HBV病毒复制及病情进展.
Objective To study the correlation analysis of hepatitis B five items tests and HBV-DNA in pregnant women with hepatitis B.Methods From January 2010 to January 2013,382 cases pregnant women with chronic hepatitis B patients in department of obstetrics and gynecology were enrolled as the observation group,with 80 cases of the same period in healthy normal pregnant women as a control group.The patients were tested serum hepatitis B five quantitative and HBV-DNA levels.Results According to hepatitis B five test results,the two groups pregnant women were divided into eight modes.HBsAg,HBeAg,HBcAb positive HBsAg,and HBeAg-positive patients had higher HBV-DNA detection rates and a higher level of HBV-DNA.The control group was not found no elevation of hepatitis B five items tests and HBV-DNA.HBV-DNA positive group HBsAg,HBeAg,and HBcAb were higher than HBV-DNA negative group（P0.05）,and HBsAb,HBeAb had a very significant difference than the control group（P0.01）.HBsAb and HBeAb showed a significant negative correlation with HBV-DNA quantitative（P0.05）.HBsAg,HBeAg,HBcAb and HBV-DNA showed a significant positive correlation（P0.01）.Conclusions Hepatitis B five items tests and HBV-DNA detection had a good correlation.Simultaneous detection of them could better reflect HBV viral replication and disease progression in patients.
出处
《昆明医科大学学报》
CAS
2013年第3期103-106,共4页
Journal of Kunming Medical University
