摘要
背景:关节软骨损伤后,软骨组织几乎没有修复能力,关节软骨损伤的修复一直是临床工作的难点。目的:探讨修复关节软骨损伤的干细胞种类及其生物学特性,明确干细胞在修复关节软骨损伤中的作用及优缺点。方法:由第一作者检索1998至2015年Pub Med数据及CNKI中国期刊全文数据库,英文检索词"Articular cartilage injury,Mesenchymal stem cells,regeneration";中文检索词"关节软骨损伤,间充质干细胞,再生",纳入47篇文献进行分析。结果与结论:关节软骨损伤最有效的修复方案是以细胞为基础的治疗方法,来源于骨髓、脂肪及脐血的间充质干细胞均有较强的成软骨特性和克隆能力。骨髓间充质干细胞具有更高的分化潜能,对软骨缺损有修复作用,来源于脐血的间充质干细胞致瘤性低,脂肪源性干细胞的生长增殖速度更快。干细胞复合天然载体材料如胶原、明胶、纤维蛋白和藻酸盐等可促进细胞黏附、分化和增殖,以此构建组织工程软骨将有效修复关节软骨缺损。
BACKGROUND： After articular cartilage injury, the injured cartilage almost has no self-healing ability. Articular cartilage injury repair has been always a difficulty in clinical work. OBJECTIVE： To explore the types and biological characteristics of stem cells for articular cartilage repair and to ensure the role and relative merits of stem cell transplantation in articular cartilage repair. METHODS： Pub Med and CNKI were retrieved by the first author for relevant articles published from 1998 to 2015 using the keywords of ＂articular cartilage injury, mesenchymal stem cells, regeneration＂ in English and Chinese, respectively. Finally, 47 articles were included in result analysis. RESULTS AND CONCLUSION： Stem cell therapy is the most effective method for repair of articular cartilage injury. Mesenchymal stem cells from bone marrow, adipose and umbilical cord have strong chondrogenic and cloning capacities. Bone marrow mesenchymal stem cells have a stronger differentiation potential, and can be used for repair of cartilage injury. Umbilical cord-derived mesenchymal stem cells have a low tumorigenicity. Adipose-derived stem cells can proliferate and grow faster. Stem cells combined with natural carrier materials, such as collagen, gelatin, fibrin and alginate, can promote cell adhesion, differentiation and proliferation, in order to build an effective tissue engineered cartilage for repair of articular cartilage defects.
出处
《中国组织工程研究》
CAS
北大核心
2015年第50期8195-8200,共6页
Chinese Journal of Tissue Engineering Research
基金
中国中医科学院眼科医院院级科研启动基金项目(201408)~~
