摘要
背景:间充质干细胞源性微囊泡和诱导性多潜能干细胞在多个领域的组织修复作用已被证实,两者有望成为修复关节软骨损伤更有效、更安全的治疗方法。目的:综述间充质干细胞源性微囊泡和诱导性多潜能干细胞促进软骨修复的研究进展。方法:由第一作者应用计算机检索Pub Med、中国期刊全文数据库(CNKI)2003年至2015年8月相关文献,英文检索词为"Articular cartilage injury,Bone marrow mesenchymal stem cells",中文检索词为"软骨损伤,骨髓间充质干细胞"。选择文章内容与干细胞治疗骨关节炎有关者,同一领域文献则选择近期发表在权威杂志文章。结果与结论:关节软骨损伤仍是骨科领域的一大难题,虽然修复方法很多,但均有局限性,而间充质干细胞源性微囊泡与诱导性多潜能干细胞的发现为软骨修复创造了可能性,同时给广大关节软骨损伤患者带来新的希望。但是,间充质干细胞源性微囊泡与诱导性多潜能干细胞大量提取及纯化方法、增殖分化潜能、在软骨修复中的作用机制等很多问题仍需要进一步解决。
BACKGROUND： Induced pluripotent stem cells and mesenchymal stem cells-derived microvesicles have been confirmed in various tissue repairs, which are expected to become more effective and safe therapy for articular cartilage repair. OBJECTIVE： To overall understand the research progress in the use of induced pluripotent stem cells and mesenchymal stem cells-derived microvesicles in articular cartilage repair. METHODS： A computer-based search of Pub Med and CNKI was performed by the first author for articles related to stem cell treatment of osteoarthritis published from 2003 to 2015. The keywords were ＂articular cartilage injury, bone marrow mesenchymal stem cells＂ in English and Chinese, respectively. In the same field, articles published recently or in authorized journals were preferred. RESULTS AND CONCLUSION： Articular cartilage injury is still a difficulty in the orthopedics. Many repair methods have been reported, but they all have limitations. Induced pluripotent stem cells and mesenchymal stem cells-derived microvesicles bring a new hope for patients with articular cartilage injury. However, there are still many problems to be solved, such as extracting and purifying a large amount of cells, proliferation and differentiation potentials, and mechanism underlying cartilage repair.
出处
《中国组织工程研究》
CAS
北大核心
2015年第41期6706-6710,共5页
Chinese Journal of Tissue Engineering Research
