摘要
目的：评价对重组人酸性成纤维细胞生长因子（recombinant human acid fibroblast growth factor,rha FGF）预防鼻咽癌放射性损伤的临床疗效和安全性。方法：选择2013年1月—2014年12月期间解放军117医院、吉林市中心医院和吉林市人民医院收治的136例鼻咽癌患者,按随机数字表法分为观察组和对照组各68例。2组患者均进行常规放射治疗,对照组患者放疗后给予0.9%氯化钠注射液喷敷及含漱,出现红斑或溃烂后应用络合碘涂擦,1日6~8次,暴露放射野皮肤至放疗结束后1周;观察组患者在对照组治疗的基础上,应用rha FGF喷敷放射野皮肤,同时应用rha FGF溶于0.9%氯化钠注射液中进行含漱。随访至放疗结束后2周,观察2组患者的皮肤、口腔黏膜、味觉损伤等情况。结果：对照组和观察组患者的（Ⅲ＋Ⅳ）度放射性皮炎发生率分别为8.82%（6/68）、36.76%（25/68）,（Ⅲ＋Ⅳ）级放射性口腔黏膜损伤发生率分别为8.82%（6/68）、29.41%（20/68）,（Ⅰ＋Ⅱ）度味觉损伤情况发生率分别为20.59%（13/68）、55.88%（38/68）,2组的差异均有统计学意义（P〈0.05）。服药期间,观察组患者的不良反应主要表现为瘙痒、恶心,未见其他严重不良反应,2组的差异无统计学意义（P〉0.05）。结论：rha FGF可以减轻鼻咽癌放疗所致皮肤、口腔黏膜及味觉损伤情况,且不良反应较少,值得临床推广。
OBJECTIVE： To evaluate the effectiveness and safety of recombinant human acidic fibroblast growth factor（ rha FGF） in prevention for radiation injury of nasal pharyngeal cancer（ NPC）. METHODS： 136 cases of patients with NPC admitted into 117 Hospital of People＇s Liberation Army,Central Hospital of Jilin and People＇s Hospital of Jilin from Jan. 2013 to Dec. 2014 were enrolled to be divided into the observation group and the control group via the random number table,with 68 cases in each group. Both groups were given the same conventional radiotherapy,after which,the observation group were treated with 0. 9% sodium chloride injection with the radiation of wound surface and mouth mucosa; and the control group received rha FGF with 0. 9% sodium chloride injection in dealing with the wound surface.Follow-up to two weeks after the end of radiotherapy,radiotherapy-induced conditions like patients＇ skin,mouth mucosa and dysgeusia in two groups were observed. RESULTS： In observation group and control group,the incidence of（ Ⅲ ＋Ⅳ） level of radiation dermatitis were respectively 8. 82%（ 6 /68） and 36. 76%（ 25 /68）; incidence of（ Ⅲ ＋ Ⅳ） level of radioactive mouth mucosal injury were respectively 8. 82%（ 6 /68） and 29. 41%（ 20 /68）; and incidence of dysgeusia were respectively 20. 59%（ 13 /68） and 55. 88%（ 38 /68）,the differences were statistically significant between two groups（ P〈 0. 05）. During medication,the adverse reactions of observation group were pruritus and nausea,but without anysever adverse reactions,there was no statistically significant difference between two groups（ P〈 0. 05）. CONCLUSIONS：rha FGF can relief the damage of patients＇ skin,mouth mucosal injury and dysgeusia that induced by radiation therapy,with few adverse reactions,which is worthy of clinical promotion.
出处
《中国医院用药评价与分析》
2015年第12期1569-1571,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
重组人酸性成纤维细胞生长因子
放射治疗
放射性皮炎
口腔溃疡
Recombinant human acidic fibroblast growth factor
Radiation therapy
Radiation dermatitis
Mouth ulcers
