摘要
目的总结斑蝥酸钠维生素B6联合同期放化疗治疗局部晚期鼻咽癌的临床效果及不良反应。方法选择2014年2月至2016年4月山西省肿瘤医院115例局部晚期鼻咽癌患者，按照随机数字表法将所有患者分为观察组（61例）和对照组（54例），观察组患者给予斑蝥酸钠维生素B6联合同期放化疗综合治疗，对照组给予放化疗治疗。对比分析两组患者的近期疗效、生命质量及不良反应情况。结果观察组患者的总获益率为93.44%（57/61），对照组为79.63%（43/54），两组差异有统计学意义（χ2=4.818，P=0.049）。观察组患者生命质量总改善率为73.77%（45/61），对照组为53.70%（29/54），两组差异有统计学意义（χ2=5.028，P=0.032）。观察组患者口腔黏膜炎、血液学毒性、咽及食管不良反应、胃肠道不良反应、皮肤纤维化的发生率均低于对照组，两组差异均有统计学意义（均P〈0.05）。结论斑蝥酸钠维生素B6联合同期放化疗治疗局部晚期鼻咽癌的近期疗效较好，不良反应发生率低，能够提高患者的生命质量。
ObjectiveTo study the clinical efficacy of sodium cantharidinate and vitamin B6 injection combined with concurrent chemoradiotherapy in treatment of locally advanced nasopharyngeal carcinoma （LA-NPC）.Methods115 patients with LA-NPC in Shanxi Cancer Hospital were randomly assigned to observation group （61 cases） and control group （54 cases） from February 2014 to April 2016. The patients in the observation group were treated with sodium cantharidate and vitamin B6 injection combined with concurrent chemoradiotherapy. The patients in the control group were treated with concurrent chemoradiotherapy. The differences between the two groups were compared in respect of recent curative effect, the quality of life （QOL） and the adverse reactions.ResultsThe recent effective rate was 93.44% （57/61） in the observation group and 79.63% （43/54） in the control group, and there was significant difference between the two groups （χ2= 4.818, P= 0.049）. The improvement rate of QOL was 73.77% （45/61） in the observation group and 53.70% （29/54） in the control group, and there was significant difference between the two groups （χ2= 5.028, P= 0.032）. The incidence rates of oral cavity mucous membrane inflammation, hematology toxicity, pharynx and esophagus adverse reactions, the gastrointestinal tract adverse reactions and skin fibrosis in the observation group were lower than those in the control group, and there were significant differences between the two groups （all P 〈 0.05）.ConclusionThe recent effect of sodium cantharidinate and vitamin B6 injection combined with concurrent chemoradiotherapy on the patients with LA-NPC is obvious. The comprehensive treatment can also reduce adverse reactions and improve the QOL.
出处
《肿瘤研究与临床》
CAS
2017年第4期262-265,共4页
Cancer Research and Clinic
关键词
鼻咽肿瘤
斑蝥酸钠维生素B6
同期放化疗
Nasopharyngeal neoplasms
Sodium cantharidinate and vitamin B6
Concurrent chemoradiotherapy
