摘要
目的通过对医院细菌耐药监测情况的分析,为临床医师制订合理、有效的抗感染治疗方案提供参考。方法采用纸片扩散法(K-B法)对医院2013年至2014年临床分离菌株进行药物敏感性试验(药敏试验)及超广谱β内酰胺酶(ESBLs)的检测,按美国临床实验室标准化协会CLSI2009-CLSI2012(M100-S19)年标准判定药物敏感性结果。结果在分离出的472株革兰阴性杆菌中,大肠埃希菌占首位。大肠埃希菌、克雷伯菌中ESBLs的检出率分别为64.41%和34.05%,肠杆菌科细菌对碳青霉烯类抗生素高度敏感,耐药率小于1%,对其他抗菌药物的敏感率低于80%,铜绿假单胞菌对各种抗菌药物的敏感率大多低于70%,鲍曼不动杆菌对各种抗菌药物敏感率大多低于70%。结论大肠埃希菌为医院肠杆菌科感染的重要致病菌。应加强监测细菌耐药性,为制订合理、有效抗感染治疗方案提供参考。
Objective Through the analysis of the hospital＇s antimicrobial resistance monitoring situation,to provide reference for formulating reasonable and effective anti- infection treatment plans for clinicians. Methods The disc diffusion method（ K- B） was used for the drug susceptibility test and clinical isolations of ESBLs test,according to the American association of clinical laboratory standardization CLSI2009- CLSI2012（ M100 approximately- S19） standard for determining the susceptibility results of the hospital during 2013-2014. Results In the 472 isolated Gram- negative bacteria,Escherichia coli accounted for first place. The detection rates of Escherichia coli and Klebsiella ESBLS were 64. 41% and 34. 05% respectively. Enterobacteriaceae was highly sensitive to carbapenems, with a resistance rate of less than 1%,and its susceptibility rate less than 80% to other antimicrobial drugs; the sensitive rates of Pseudomonas aeruginosa to a variety of antibiotics were mostly below 70%; the sensitivity rate of Acinetobacter baumannii to various antibacterial drugs were more than 70%. Conclusion Escherichia coli infection is an important pathogen in the hospital. We should strengthen the monitoring of bacterial resistance for the development of rational and effective anti- infection treatment programs
出处
《中国药业》
CAS
2016年第1期70-72,共3页
China Pharmaceuticals
关键词
耐药性
药物敏感性试验
革兰阴性菌
抗菌药物
resistance
drug susceptibility test
gram-negative bacteria
antibacterials
