摘要
组织器官在生理或病理状态下,受到促血管生成因子的刺激,引发生血管新生。VEGF、Notch、Wnt/β-catenin、Ang1(2)/tie2、PI3K-AKT等多个信号通路参与到该过程,对血管新生的各个阶段产生影响。其中VEGF联系众多信号通路,对血管新生整个过程进行调节,发挥了无可替代的作用。近年来国内外对VEGF及相关信号通路调节血管新生机制的研究取得了一定的进展,对多种疾病发病机制的阐明及临床药物的研发提供了新的理论依据。我们总结了近年来相关研究成果,希望为血管新生相关疾病的治疗提供新的可能性。
Tissues and organs generate angiogenesis under the stimulation of angiogenic factors in physiological or pathological conditions. Multiple signal pathways including VEGF,Notch,Wnt / β-catenin,Ang1（ 2） / tie2 and PIK-Akt etc. have effects on various stages of angiogenesis. VEGF exerts irreplaceable effects on the whole process of angiogenesis through multiple signal pathways. Over the past few years,new progress has been made in the researches of mechanisms regulating angiogenesis through VEGF-related signal pathways both at home and abroad. These findings provide us new theoretical basis for clarification of the pathogenesis of many diseases and clinical drug development. In this article we will summarize the recent research progress in this field,hoping to provide new possibilities for the treatment of angiogenesisrelated diseases.
出处
《中国比较医学杂志》
CAS
北大核心
2015年第12期81-86,共6页
Chinese Journal of Comparative Medicine
基金
"重大新药创制"科技重大专项
项目编号:2012ZX09102201-106
国家自然科学基金项目编号:81373994
