摘要
目的探讨<34周早产儿解脲脲原体(UU)感染的临床特征。方法选取232例<34周早产儿,用实时荧光定量聚合酶链反应法检测入院24h内下呼吸道分泌物中UU,并分为阳性和阴性组,比较其临床特征的差异。结果232例早产儿中,UU阳性97例;阳性组平均胎龄和出生体质量均低于阴性组,差异有统计学意义(P均<0.01)。两组间性别、母亲妊娠期高血压、产前使用激素、围生期窒息的差异无统计学意义(P>0.05),阳性组母亲绒毛膜羊膜炎、胎膜早破、经阴道分娩率均高于阴性组,差异有统计学意义(P<0.01)。生后24h、72h,阳性组的白细胞及中性粒细胞计数均较阴性组增高,差异有统计学意义(P<0.05)。阳性组出生1周后肺部损伤较阴性组明显,差异有统计学意义(P<0.05)。阳性组呼吸机撤机后需重新机械通气,以及第10天仍需机械通气的比例高于阴性组,差异有统计学意义(P均<0.05)。出生28d时,阳性组支气管肺发育不良发生率高于阴性组,急性呼吸窘迫综合征发生率低于阴性组,差异均有统计学意义(P均<0.05);两组间早产儿视网膜病、脑室内-脑室周围出血、脑室周白质软化、新生儿坏死性小肠结肠炎及出院时宫外发育迟缓发生率的差异无统计学意义(P>0.05)。结论<34周以下早产儿下呼吸道分泌物UU检测阳性可能与早产、低出生体质量有关,并可引起慢性肺部损伤。
Objective To investigate the clinical features of Ureaplasma urealyticum （UU） infection in preterm infants under 34 weeks＇ gestation. Methods A total of 232 preterm infants under 34 weeks＇ gestation were enrolled. The UU in the lower respiratory tract secretions from infants within 24 hours of admission were detected by real-time fluorescence quantitative polymerase chain reaction. According to the results, infants were divided into positive and negative groups. The differences of the clinical features were compared between two groups. Results Ninety-seven infants were UU positive in 232 preterm infants. The gestational age and birth weight of the positive group were lower than those of negative group （all P〈0.01）. The difference in sex, maternal gestational hypertension, prenatal use of hormones and perinatal asphyxia between two groups were not significant （P〉0.05）. The rates of histologic chorioamnionitis, premature rupture of membranes and vaginal delivery in the positive group were higher than those in the negative group （P〈0.01）. At 24 and 72 hours after birth, the number of leukocytes and neutrophils in the positive group were significantly higher than those in the negative group （P〈0.05）. One week after birth, the lung injury was more serious in the positive group than that in the negative group （P〈0.05）. The rates of re-ventilation during ventilator weaning and needs of ventilator after l0 days were higher in the positive group than those in the negative group. At 28 days after birth, the rate of the bronchial dysplasia was higher in the positive group than that in the negative group （P〈 0.05） and the rate of acute respiratory distress syndrome was lower in the positive group than that in the negative group （P〈0.05）. The rates of retinopathy, periventricular-intraventricular hemorrhage, periventricular leukomalacia, neonatal necrotizing enterocolitis and extrauterine growth retardation were not different between the two groups （all P〈0.01）. Conclusi
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2016年第1期1-6,共6页
Journal of Clinical Pediatrics
关键词
解脲脲原体
早产儿
围生期
Ueaplasma urealyticum
preterm infants
perinatal
