摘要
口服或局部使用抗生素类药物为治疗痤疮的主要方法之一,但是抗生素耐药问题日趋严重。痤疮丙酸杆菌(PA)耐药目前发现主要与点突变有关。各国PA耐药情况大致相同:红霉素、克林霉素耐药较高,四环素、二甲胺四环素较低;耐药发生率与既往使用抗生素情况、病史长短相关。仅有个别抗生素耐药情况存在较大差异,可能与各国抗生素使用习惯及频率有关。非抗生素类药物如:抗菌肽二聚物A3-APO及其单体代谢物或中药提取物等在体外均有抑制PA的作用,且抑菌机制均不同于抗生素,在治疗痤疮过程中可将这些药物与抗生素联合应用,从而减少耐药的发生,提高临床疗效。
Oral or topical use of antibiotic drugs is one of the main methods for the treatment of acne, but the prob- lem of antibiotic resistance becomes worse and worse. Recent studies have found that Propionibacterium acnes（PA） resistance is mainly related to the point nmtations. The PA resistance is roughly same in all countries. Erythromycin, clindamycin resistance is high, and tetracycline, minocycline is low; Drug resistance rate is associated with the use of antibiotics and previous medical history, length. The non-antibiotic medicines, such as antibacterial peptide dimer A3 - APO and monomer metaholites or herbal extracts in vitro were to inhibit the action of the PA, and its antibacterial mechanism are different form antibiotics, so these drugs were used combination with antibiotics for the treatment of acne, which result in reduced occurrence of antibiotic resistance, improved clinical curative effect.
出处
《皮肤病与性病》
2015年第6期323-325,共3页
Dermatology and Venereology
关键词
痤疮
痤疮丙酸杆菌
抗生素耐药
Acne
Propionibacterium acnes
Antibiotic resistance
