摘要
糖皮质激素和性激素是参与类风湿性关节炎(rheumatoid arthritis,RA)疾病治疗的主要类固醇激素,发挥着强效快速的治疗作用。本文介绍了糖皮质激素和性激素与炎症因子,免疫反应,核受体之间的关系及治疗RA的安全有效性,阐明两者治疗RA可能的作用机制,综述了类固醇激素与RA的潜在联系,为更好地使用类固醇激素治疗RA及开发治疗RA的新药提供理论参考。
Steroids have been used to treat rheumatoid arthritis（RA）, especially glucocorticoids and sex hormones, exhibit powerful and rapid therapeutic effects. The relationship between the steroids and inflammatory cytokine, immune response, nuclear receptors, as well as the safety and efficacy of RA treatment, were introduced in this review. Meanwhile, the possible mechanism of glucocorticoids and sex hormones therapy were discussed. The potential relevance of steroids to RA was also discussed to better use steroids in the treatment of RA and to provide references for future research.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2015年第6期757-763,共7页
Journal of China Pharmaceutical University
基金
国家自然科学基金资助项目(No.81303301)~~
