摘要
目的：探讨血清中视黄醇结合蛋白4（RBP4）和网膜素-1（omentin-1）与颈动脉狭窄缺血性脑卒中的关系。方法选取50例对照人群，143例颈动脉狭窄缺血性脑卒中患者。缺血性脑卒中患者根据超声多普勒分为轻度狭窄组（颈动脉正常或狭窄＜50%，67例）、中度狭窄组（颈动脉狭窄50%～70%，45例）和重度狭窄组（颈动脉狭窄〉70%至接近闭塞，31例）。自动生化分析仪检测各组体质指数（BMI）、高血压情况、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和空腹血糖（FPG），用ELISA法检测各组血清中RBP4和omentin-1的含量，分析颈动脉狭窄缺血性脑卒中的危险因素。结果中、重度颈动脉狭窄组合并高血压比例明显多于对照组及轻度狭窄组（P＜0.05），血清TC、TG、LDL-C、FPG和RBP4水平明显高于对照组（P＜0.05），而omentin-1水平明显低于对照组（P＜0.05）。Logistic回归显示高TC、RBP4是颈动脉狭窄缺血性脑卒中的危险因素，而高omentin-1是保护因素。结论脂肪因子RBP4是发生颈动脉狭窄缺血性脑卒中的危险因素而omentin-1是保护因素。
Objective To investigate the correlation of serum levels of retinol binding protein 4 （RBP4） and andomentin-1 with ischemic stroke and carotid artery stenosis. Methods Healthy adult （n=50） were selected as the control group while ischemic stroke patients with different degrees of carotid artery stenosis （n=143） were enrolled as the disease group. According to the ultrasonic Doppler performance, these ischemic stroke patients were divided into three groups：mild stenosis group （carotid artery stenosis was normal or less than 50%, n=67）, moderate stenosis group （carotid artery stenosis was 50%to 70%, n=45）, severe stenosis group （carotid artery stenosis was 70%to total occlusion, n=31）. BMI index, hypertension, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL）, low density lipoprotein （LDL） and fasting blood glucose （FPG） were detected by Automatic biochemical analyzer and serum levels of RBP4 and omentin-1 were measured by ELISA. Results Hypertensive population in carotid artery stenosis group was larger than that in control group （P〈0.05）. Serum TC, TG, LDL, FPG and RBP4 levels were significantly higher while omentin-1 level decreased remarkably in disease group than those in the control group （P〈0.05）. Logistic regression analysis showed that TC and RBP4 were the risk factors of ischemic stroke with carotid artery stenosis, while omentin-1 was a protective factor. Conclusion RBP4 is a risk factor for ischemic stroke with carotid artery stenosis and omentin-1 is a protective factor.
出处
《天津医药》
CAS
2015年第12期1424-1427,共4页
Tianjin Medical Journal
