摘要
目的探究H型高血压合并急性缺血性脑卒中患者血清可溶性凝集素样氧化型低密度脂蛋白受体-1(sLOX-1)、网膜素-1(omentin-1)水平变化,及其与病情严重程度及预后的关系。方法选取本院2017年2月至2018年5月136例H型高血压合并急性缺血性脑卒中患者作为观察组,选取同期136例H型高血压非急性缺血性脑卒中患者作为对照组,检测研究对象血清sLOX-1、omentin-1水平。观察组患者根据美国国立卫生研究院卒中量表(NIHSS)评分分为轻症组、中症组和重症组;并根据改良RANKIN量表(mRS)评分将其分为预后良好组和预后不良组,分析H型高血压合并急性缺血性脑卒中患者血清sLOX-1和omentin-1的水平与病情严重程度和预后的关系。结果观察组患者血清sLOX-1水平明显高于对照组,而血清omentin-1水平明显低于对照组(均P <0.05)。血清sLOX-1水平随病情严重程度增加而升高,而血清omentin-1水平随病情严重程度增加而降低(均P <0.05)。预后良好组患者血清sLOX-1水平明显低于预后不良组,而血清omentin-1水平明显高于预后不良组(均P <0.05)。血清sLOX-1水平与NIHSS评分和mRS评分呈正相关,血清omentin-1水平与NIHSS评分和mRS评分呈负相关(均P <0.05)。结论血清sLOX-1和omentin-1的水平与H型高血压合并急性缺血性脑卒中患者的病情严重程度和预后密切相关,可作为H型高血压合并急性缺血性脑卒中患者病情严重程度和预后判断的辅助标志物。
Objective To investigate the changes of soluble lectin-like oxidized low-density lipoprotein receptor-1(sLOX-1)and omentin-1 in patients with H-type hypertension complicated with acute ischemic stroke, and to analyze the correlation of sLOX-1 and omentin-1 levels with the severity and prognosis of the disease. Methods Totally 136 patients with H-type hypertension complicated with acute ischemic stroke from February 2017 to May 2018 were selected as observation group,and 136 non-acute ischemic stroke patients with H-type hypertension in the same period as the control group. The patients of observation group were divided into mild, moderate and severe sub-groups according to NIHSS score,and they were also divided into good prognosis group and poor prognosis group based on modified RANKIN scale(mRS)score. The serum sLOX-1 and omentin-1 levels were detected,and the correlation of sLOX-1 and omentin-1 levels with severity and prognosis of disease was analyzed. Results The serum sLOX-1 level of the observation group was higher,but the serum omentin-1 level lower than that of control group(P < 0.05). With the severity of the disease,the serum sLOX-1 level increased,but the serum omentin-1 level decreased(P < 0.05). The serum sLOX-1 level of good prognosis group was significantly lower,whereas the serum omentin-1 level significantly higher than that of poor prognosis group(P < 0.05). sLOX-1 was positively correlated with NIHSS score and mRS score,while omentin-1 was negatively correlated with NIHSS score and mRS score(P < 0.05). Conclusions The levels of serum sLOX-1 and omentin-1 are closely related to the severity and prognosis of patients with H-type hypertension complicated with acute ischemic stroke,which could be used as markers for evaluating the severity and prognosis of the patients.
作者
程启慧
余丹
杨国帅
周艳辉
周峰
孙荣道
刘春苗
周律
CHENG Qihui;YU Dan;YANG Guoshuai;ZHOU Yanhui;ZHOU Feng;SUN Rongdao;LIU Chunmiao;ZHOU Lü(Department of Neurology,Haikou People′ s Hospital(Haikou Hospital Affiliated to Xiangya School of Medicine,Central South University),Haikou 570208,China)
出处
《实用医学杂志》
CAS
北大核心
2019年第3期346-349,共4页
The Journal of Practical Medicine
基金
海南省卫生计生行业科研项目(编号:18A200174)
海南省自然科学基金项目(编号:20158272)
