摘要
目的探讨血清β-绒毛膜促性腺激素(β-HCG)和孕酮(PROG)检测在胚胎移植后先兆流产早期诊断中的临床意义。方法 60例胚胎移植后早孕孕妇分为正常妊娠组(n=20例)、先兆性流产组(n=20例)和流产组(n=20例)。比较3组孕妇血清PROG和β-HCG水平。结果胚胎移植后妊娠第15、16、17 d,流产组孕妇的血清孕酮水平比其他两组低,但无统计学意义,先兆性流产组孕妇的血清孕酮水平和正常妊娠组无显著差异。三组孕妇之间、不同时间之间β-HCG水平差异有统计学意义(组间差异和组内差异P<0.05),流产组孕妇β-HCG水平显著低于先兆流产组(P<0.05),先兆流产组显著低于正常妊娠组(P<0.05)。结论血清孕酮、β-HCG对于胚胎移植后早期先兆流产的诊断具有指导意义;血清孕酮与β-HCG联合检测能够提高早期先兆流产患者妊娠结局预测的敏感性和准确率,有效指导患者的治疗,提高治疗效果,减少患者的经济负担。
Objective To study the clinical effect of Dynamic monitoring serum beta human chorionic gonadotropin（β- HCG） and progesterone（PROG） on early diagnosis of threatened abortion after embryo transfer. Methods 60 pregnant women after carrying out embryo transfer were divided into normal pregnant group, threatened abortion group and abortion group according to their clinical manifestations, 20 cases in each group.And serum progesterone and β- HCG levels were compared in all groups. Results At 15 th,16th, 17 th day of the pregnancy, serum progesterone level in the abortion group was lower than that in other two groups, but it was not statistically significant. There was no significant difference in serum progesterone level between normal pregnancy group and threatened abortion group. There were significant difference on β- HCG level between three groups and one group in different time（P〈0.05）. Theβ- HCG level in the abortion group was significantly lower than that in the threatened abortion group（P〈0.05）, and the β- HCG level in the threatened abortion group was significantly lower than that in the normal pregnancy group（P〈0.05）. Conclusion Serum progesterone and β- HCG are highly instructive for IVF- ET early diagnosis of threatened abortion. The serum progesterone and β- HCG combined detection can improve the sensitivity and accuracy of the prediction for the patients with threatened abortion, effectively guide the treatment,improve the therapeutic effect and reduce patients＇ economic burdens.
出处
《新疆医学》
2015年第11期1595-1597,共3页
Xinjiang Medical Journal
