摘要
癌性神经病理性疼痛（NCP）是肿瘤患者由于外周或者中枢神经系统或者神经传导系统受到物理性或化学性损伤引起的疼痛，其发病机制包括肿瘤压迫引起的神经痛、手术与放化疗等治疗引起的神经痛、副瘤综合征引起的神经痛以及炎症等其他因素引起的神经痛。详细的病史询问、仔细的体格检查是诊断NCP的重要手段，其临床评估应使用标准化的疼痛评估量表。目前，NCP的治疗主要包括阿片类为主的药物联合辅助镇痛药物、介入治疗和基因治疗。针对NCP的发病机制决定治疗策略，多学科协作、联合不同止痛药物及技术手段是治疗NCP的方向。
Neuropathic cancer pain （NCP） arises from physical or chemical damage to peripheral or central neurons or in the neural conduction system. The mechanisms of NCP include pain directly related to tumor involvement, pain associated with chemotherapy, radiotherapy and surgery, neuropathic syndromes asso- ciated with paraneoplastic syndromes, inflammation and other factors. A detailed history and careful physical examination are important means of diagnosis of NCP. The clinical evaluation of NCP should use standardized pain assessment scale. Till now, the treatments of NCP include opioid combined with auxiliary analgesic drugs, interventional treatment and gene treatment. Deciding treatment strategies according to the pathogenesis of NCP, muhidiseiplinary collaboration, combined therapy with different analgesic drugs and technologies are the therapeutic directions for NCP.
出处
《国际肿瘤学杂志》
CAS
2015年第12期946-949,共4页
Journal of International Oncology
基金
国家自然科学基金（81201065）
天津医科大学肿瘤医院院级科研种子基金（1419）
关键词
肿瘤
神经痛
诊断
治疗
Neoplasms
Neuralgia
Diagnosis
Therapy
