摘要
目的：探讨奥施康定联合岩舒注射液治疗中重度肺癌疼痛的临床疗效。方法：肺癌中重度疼痛患者98例,按照随机数字的方法分为对照组和观察组,每组49例患者,对照组患者使用奥施康定进行治疗,观察组患者在对照组治疗方法基础上使用岩舒注射液,对治疗的效果进行对比。结果：观察组患者完成治疗之后的疼痛缓解情况优于对照组患者,数据差异具有统计学意义（z=2. 879,P 〈0. 05）,观察组患者的奥施康定使用量低于对照组患者,而且随着治疗时间延长,奥施康定使用量逐渐降低,数据差异具有统计学意义（P 〈0. 05）,两组患者的平均镇痛起效时间,平均镇痛时间与平均滴定达到稳态时间数据差异均不具有统计学意义（P〉 0. 05）,观察组患者生活质量提高幅度高于对照组患者,观察组患者的各项不良反应发生率均低于对照组患者,数据差异均具有统计学意义（P 〈0. 05）。结论：利用奥施康定联合岩舒注射液治疗中重度肺癌疼痛的患者,可以提高疼痛缓解率,改善患者的生活质量,减少奥施康定使用量和不良反应发生率,值得在临床范围内进行推广。
Objective：To investigate the clinical effect of Oxycontin and Yanshu Injection on moderate-severe lung cancer pain. Methods： 98 severe lung cancer patients,according to the random number method were divided into control group and observation group,49 patients in each group. Patients in the control group were treated with Oxycontin. Patients in the observation group were treated with Yanshu Injection on the basis of the control group,and the treatment effect was compared. Result： Patients in the observation group had better pain relief after completing the treatment than those in the control group,and the difference was statistically significant（ z = 2. 879,P〈0. 05）. Oxycontin in observation group was lower than that in control group. With the prolongation of treatment time,the dosage of Oxycontin decreased gradually and the difference was statistically significant（ P〈0. 05）. There was no significant difference between the two groups in the mean time to onset of analgesia,the mean time to analgesia or the mean time to steady-state data（P〉0. 05）. The quality of life of the observation group increased more than that of the control group. The incidence ofadverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant（ P〈0. 05）. Conclusion： Oxycodin combined with Yanshu Injection for patients with moderate to severe lung cancer pain can improve the pain relief rate and improve the quality of life of patients and reduce the amount of oxycodone and the incidence of adverse reactions,it is worthy of clinical promotion.
作者
李侠
徐玉芬
宋斌斌
杨新妹
徐龙生
倪桦栋
方志仙
陈文宇
LI Xia;XU Yufen;SONG Binbin;YANG Xinmei;XU Longsheng;NI Huadong;FANG Zhixian;CHEN Wenyu(Department of Oncology,Jiaxing First Hospital,Jiaxing 314000,Zhejiang,China;Central Laboratory,Jiaxing First Hospital,Jiaxing 314000,Zhejiang,China;Department of Pain,Jiaxing First Hospital,Jiaxing 314000,Zhejiang,China;Department of Respiration,Jiaxing First Hospital,Jiaxing 314000,Zhejiang,China)
出处
《中华中医药学刊》
CAS
北大核心
2018年第10期2525-2529,共5页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省医学会临床科研基金项目(2013ZYC-A89)
浙江省浙北区域专病中心-麻醉科项目[浙卫发(2015)21号]
嘉兴市重点学科肿瘤学、呼吸病学建设项目(04-F-14、04-Z-11)
嘉兴市肺癌的早期诊断和综合治疗创新团队建设项目[嘉委办发(2015)3号]
嘉兴市第一医院科技创新人才培养项目(2016-CX-04、2016-CX-05)
嘉兴市第一医院院级项目(2016QMX003)
