摘要
目的探讨侧脑室增宽胎儿的染色体产前诊断和妊娠结局情况。方法选取2011年1月-2013年12月该院因胎儿侧脑室增宽进行产前诊断的107例单胎孕妇为研究组,另选取同期错过血清学筛查或因高龄进行产前诊断的50例单胎孕妇为对照组。对比分析两组产前诊断结果、妊娠结局及新生儿出生情况。结果中、重度侧脑室增宽组染色体异常的发生情况与对照组比较,差异有统计学意义(P<0.05)。非孤立性侧脑室增宽组新生儿神经系统发育异常率与对照组比较,差异有统计学意义(P<0.05)。结论中、重度胎儿侧脑室增宽与胎儿染色体核型异常存在相关性,在孕期应进行产前诊断,排除胎儿染色体异常。排除染色体异常后,非孤立性侧脑室增宽胎儿的预后明显低于正常新生儿。
Objective To explore chromosomal prenatal diagnosis and pregnancy outcome of fetal lateral ventriculomegaly. Methods A total of 107 women of single pregnancy receiving prenatal diagnosis because of fetal ventriculomegaly in the hospital from January 2011 to December 2013 were selected as study group, 50 women of single pregnancy receiving prenatal diagnosis because of advanced age or missing serological screening during the same period were selected as control group; the results of prenatal diagnosis, pregnancy outcomes, and neonatal birth situations in the two groups were compared and analyzed. Results There was statistically significant difference in the incidence rate of chromosomal abnormalities between moderate and severe fetal ventriculomegaly patients in study group and control group （P〈 0. 05 ） ; there was statistically significant difference in abnormal rate of neonatal nervous system between nonisolated fetal ventriculomegaly patients in study group and control group （P〈0. 05 ） . Conclusion Moderate and severe fetal ventriculomegaly is correlated with fetal chromosomal karyotype abnormalities, prenatal diagnosis should be conducted during pregnancy to exclude fetal chromosomal abnormalities; after excluding chromosomal abnormalities, the prognosis of nonisolated fetal ventrieulomegaly patients is significantly poorer than that of normal neonates.
出处
《中国妇幼保健》
CAS
2015年第34期6058-6060,共3页
Maternal and Child Health Care of China
基金
广西医学高层次骨干人才培养"139"计划
关键词
侧脑室增宽
产前诊断
妊娠结局
Ventriculomegaly
Prenatal diagnosis
Pregnancy outcome
