摘要
目的探讨复发缓解型多发性硬化(RRMS)患者脑脊液及血清中非髓鞘神经相关蛋白的水平及其临床意义。方法选择2010年1月至2014年12月我院收治的70例RRMS患者作为观察组,同期来我院体检的70例健康体检者作为对照组,分别比较两组受试者的脑脊液与血清中的非髓鞘神经相关蛋白水平(包括14-3-3蛋白、S100蛋白及tau蛋白)。结果观察组患者脑脊液中的14-3-3蛋白、S100蛋白及tau蛋白水平均较对照组高,两组比较差异均有统计学意义(P<0.05);观察组患者血清中的14-3-3蛋白、S100蛋白及tau蛋白水平分别与对照组比较,差异均无统计学意义(P>0.05)。结论复发缓解型多发性硬化患者脑脊液中14-3-3蛋白、S100蛋白及tau蛋白非髓鞘神经相关蛋白均有明显升高现象,可以作为该病的检查指标,而血清中非髓鞘神经相关蛋白则无明显变化。
Objective To investigate the detection and clinical significance of non-myelinated nerve associat-ed proteins in cerebrospinal fluid （CSF） and serum of patients with relapsing-remitting multiple sclerosis （RRMS）. Methods Seventy patients with RRMS in our hospital from January 2010 to December 2014 were enrolled as the ob-servation group, and 70 healthy people in our hospital for health examination at the same period were considered as the control group. The levels of non-myelinated nerve associated proteins （including 14-3-3 protein, S100 protein and tau protein） were analyzed and compared between the two groups. Results The levels of 14-3-3 protein, S100 pro-tein and tau protein in cerebrospinal fluid in the observation group were significantly higher than those in the control group （P〈0.05）, but the levels of the proteins in serum showed no statistically significant difference between the two groups （P〉0.05）. Conclusion The levels of non-myelinated nerve associated proteins in cerebrospinal fluid are sig-nificantly increased in patients with relapsing-remitting multiple sclerosis, which can be used as indicators of the dis-ease. However, the levels showed no significant change in serum of the patients.
出处
《海南医学》
CAS
2015年第21期3165-3167,共3页
Hainan Medical Journal
基金
四川省卫生厅自然基金(编号:110104)
关键词
多发性硬化
脑脊液
血清
非髓鞘神经相关蛋白
Multiple sclerosis
Cerebrospinal fluid
Serum
Non-myelinated nerve associated proteins
