摘要
目的:观察血府逐瘀汤加味治疗心绞痛瘀血阻络证的临床疗效。方法:将符合纳入标准90例患者按随机分为治疗组(50例)和对照组(40例)。对照组给予西医常规治疗,治疗组在对照组的基础上给予血府逐瘀汤加味,3个月为1个疗程,共治疗2个疗程,疗程结束后,观察比较两组患者心绞痛症状积分、中医证候积分、血液流变学、高敏C-反应蛋白、血脂等指标的变化,评价临床疗效及作用机理。结果:1治疗组显效35例,有效13例,无效2例,有效率为96.00%;对照组显效17例,有效14例,无效9例,有效率为77.50%。两组比较,差异有统计学意义(P<0.05);2治疗后治疗组中医证候积分(5.08±2.74)分,对照组中医证候积分(8.17±3.66)分,两组比较,差异有统计学差异(P<0.05);3治疗后治疗组心绞痛瘀血阻络证症状积分(3.56±2.41)分,对照组心绞痛瘀血阻络证症状积分(7.32±3.54)分,两组比较,差异有统计学差异(P<0.05);4治疗后两组高切黏度、低切黏度、血浆黏度、纤维蛋白原比较,治疗组明显优于对照组,差异有统计学意义(P<0.05);5治疗后两组血脂、高敏C-反应蛋白比较,差异有统计学意义(P<0.05)。结论:血府逐瘀汤加味能够明显缓解心绞痛瘀血阻络证患者的临床症状,能够降低心绞痛瘀血阻络证患者的发作次数、疼痛持续时间、疼痛程度,且疗效较好,安全性高。且能够降低患者的血脂水平和高敏C-反应蛋白,改善患者血液流变学,提示血府逐瘀汤加味治疗心绞痛瘀血阻络证的作用机理可能与改善患者血脂、血液流变学、高敏C-反应蛋白等有关。
Objective： To observe the therapeutic of Xuefuzhuyu decoction in treating angina pectoris. Methods： 90 patients included in the standard were randomly divided into the treatment group（ 50 cases） and control group（ 40 cases）. The control group was given conventional western medicine treatment and the treatment group was given additional Xuefuzhuyu decoction,3 months for a period of treatment,two courses of treatment. After the treatment,observe and compare the angina pectoris symptom scores,TCM syndrome score,blood rheology,C-reactive protein,blood lipids and other indicators of change of two groups and evaluate the clinical curative effect and mechanism of action. Results： 1In the treatment group： 35 cases were markedly effective,13 cases in effective,2 cases invalid,the effective rate was 96. 00%. Control group： 17 cases had marked effect,14 cases in effective,9 cases invalid,the effective rate was77. 50%. Compared the two groups,the difference was statistically significant（ P〈0. 05）; 2 The TCM syndrome score was（ 5. 08 ±2. 74） in treatment group and（ 8. 17 ± 3. 66） in the control group. Compared the two groups,there had statistically significant（ P〈0. 05）; 3The symptoms integral was（ 3. 56 ± 2. 41） in treatment group and（ 7. 32 ± 3. 54） in control group. Compared the two groups,there had statistically significant（ P〈0. 05）; 4Compared the high shear viscosity,low shear viscosity,plasma viscosity and fibrinogen of two groups,the treatment group was better than that of control group,the difference was statistically significant（ P〈0. 05）; 5Compared the blood fat,C-reactive protein of two groups,there was statistically significant（ P〈0. 05）. Conclusion： Xuefuzhuyu decoction can obviously alleviate clinical symptoms of angina pectoris patients with blood stasis,can reduce attack frequency of angina patients,duration of pain,pain degree,and has good curative effect,high safety. Can reduce the patient＇ s blood lipid levels and C-reactive protein,im
出处
《中医学报》
CAS
2015年第11期1656-1658,共3页
Acta Chinese Medicine
