摘要
目的评价加味血府逐瘀汤结合西医常规疗法治疗非动脉炎性前部缺血性视神经病变(non arteritis anterior ischemic optic neuropathy, NAION)的疗效。方法将符合入选标准的87例NAION患者,采用随机数字表法分为对照组43例和研究组44例,对照组给予常规疗法联合复方樟柳碱注射液治疗,研究组给予常规疗法联合加味血府逐瘀汤治疗。2组均治疗28 d。采用标准对数视力表检测并记录最佳矫正视力,采用视野程序(Oc-topus-101)记录患者视野光敏度、视野缺损,采用彩色多普勒超声技术测量睫状后短动脉收缩期峰值血流速度(systolic peak blood flow velocity, PSV)、舒张末期血流速度(end diastolic velocity, EDV)、阻力指数(resistance index, RI),评价临床疗效。结果研究组总有效率为97.7%(43/44)、对照组为76.7%(33/43),2组比较差异有统计学意义(χ2=8.669,P=0.003)。治疗后,研究组最佳矫正视力[(0.85±0.21)比(0.72±0.32),t=2.245]、视野光敏度[(18.71±4.79)j/db比(16.32±5.22)j/db,t=2.226]均高于对照组(P<0.05);视野缺损[(6.06±1.52)j/db比(8.13±2.43)j/db,t=4.775]低于对照组(P<0.05);PSV[(10.03±1.79)cm/s比(8.85±1.88)cm/s,t=2.999]、EDV[(3.06±0.37)cm/s比(2.67±0.31)cm/s,t=5.323]高于对照组(P<0.05),RI[(0.61±0.08)比(0.69±0.09),t=4.385]低于对照组(P<0.05)。结论加味血府逐瘀汤结合西医常规疗法可有效改善NAION患者的睫状后短动脉血流动力学及视功能,提高临床疗效。
Objective To evaluate the efficacy of modified Xuefu-Zhuyu decoction in the treatment of nonarteritic anterior ischemic optic neuropathy (NAION). Methods A total of 87 patients with NAION who met the inclusion criteria were divided into control group (43 cases) and study group (44 cases) by the random number table method. The control group was given the routine treatment combined with compound anisodine injection, while the study group was treated with routine treatment combined with modified Xuefu-Zhuyu decoction. Both groups were treated for 28 days. The standard logarithmic visual acuity chart was used to detect and record the best corrected visual acuity. The Visual field photosensitivity and visual field defect was recorded by visual field program(Oc-topus-101). The systolic peak blood flow velocity (PSV), end diastolic velocity (EDV), resistance index (RI) of the posterior ciliary short artery were measured by color Doppler ultrasound. The clinical effect was evaluated. Results The total effective rate was 97.7%(43/44) in the study group and 76.7%(33/43) in the control group. There were significant differences between the two groups (χ2=8.669, P=0.003). After treatment, the best corrected visual acuity (0.85 ± 0.21 vs. 0.72 ± 0.32 , t=2.245), visual field photosensitivity (18.71 ± 4.79 φ/db vs. 16.32 ± 5.22 φ/db, t=2.226) in the study group was significantly higher than those in the control group (P<0.05);the visual field defect (6.06 ± 1.52 φ/db vs. 8.13 ± 2.43 φ/db, t=4.775) in the study group was significantly lower than that of the control group (P<0.05);the PSV (10.03 ± 1.79 cm/s vs. 8.85 ± 1.88 cm/s, t=2.999), EDV (3.06 ± 0.37 cm/s vs. 2.67 ± 0.31 cm/s, t=5.323) in the study group was significantly higher than those of the control group (P<0.05), RI (0.61 ± 0.08 vs. 0.69 ± 0.09, t=4.385) in the study group was significantly lower than that of control group (P<0.05). Conclusions The modified Xuefu-Zhuyu decoction combined with conventional medicine can effectively improve the hemodynam
作者
徐怡
尹靓瑶
李景翠
Xu Yi;Yin Liangyao;Li Jingcui(Department of Ophthalmology, Binzhou Central Hospital, Binzhou 251700, China)
出处
《国际中医中药杂志》
2019年第8期821-824,共4页
International Journal of Traditional Chinese Medicine
关键词
视神经病变
缺血性
视觉障碍
血府逐瘀汤
视野
血液流变学
中西医结合疗法
Optic neuropathy
ischemic
Vision disorders
Xue Fu Zhu Yu Tang
Visual fields
Hemorheology
Integrated Chinese traditional and western medicine therapy
