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223例新生儿ABO溶血病血清学试验结果的分析 被引量:5

Analysis on serological test results in 223 cases of neonatal ABO hemolytic disease
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摘要 目的通过分析新生儿ABO溶血病血清学实验室检测的结果,了解不同检测时间段患儿阳性率的差异;血清学三项试验阳性率的差异;不同母婴血型组合阳性率的差异。方法对223例临床怀疑为新生儿ABO溶血病患儿的标本根据不同检测时间段分为4组,分别为出生1d组、2d组、3d组、〉3d组;根据母婴血型组合分为O-A组合和O-B组合。各组均进行血型鉴定及改良直接抗人球蛋白试验、抗体游离试验、抗体热放散试验,并比较各组检测结果。结果新生儿ABO溶血病实验室检测:出生1d组阳性率为89.8%,2d组阳性率为90.9%,3d组阳性率为87.0%,〉3d组阳性率为76.7%,出生1-3d阳性率较集中,且随着时间的延长,阳性率呈下降趋势。O-A组阳性率88.6%,O-B组阳性率77.1%,O-A组阳性率明显高于O-B组。结论血清学三项试验中抗体热放散试验的阳性率高于改良直接抗人球蛋白试验及抗体游离试验,放散试验是"三项试验"中判定ABO-HDN最有力的证据。 Objective To understand the difference of neonatal positive rates among different detection periods,difference of positive rates in serological 3items tests and difference of positive rates among different combinations of maternal and neonatal blood groups by analyzing the laboratory detection results in ABO hemolytic disease of newborn(ABO-HDN).Methods The samples from 223 cases of clinically suspected ABO-HDN were divided into 4groups of birth 1,2,3,〉3daccording to different detection periods and the O-A combination group and O-B combination group according to maternal and neonatal blood type.The various groups were performed the blood type identification,improved direct antiglobulin testing(DAT),antibody free test and antibody thermal radiation test.The detection results were compared among various groups.Results In the results of ABO-HDN laboratory detection:the positive rates in the birth 1,2,3,〉3dgroups were 89.8%,90.9%,87.0% and 76.7% respectively,the positive rates were relatively concentrated on birth 1-3d,moreover with the extension of time,the positive rate showed the decreasing trend;the positive rates in the O-A group and the O-B group were 88.6% and 77.1% respectively,the positive rate in the O-A group was obviously higher than that in the O-B group.Conclusion The positive rate in the thermal radiation test is higher than that in the improved DAT and antibody free test.The elution test is the most powerful evidence for judging ABO-HDN.
出处 《检验医学与临床》 CAS 2015年第21期3219-3220,共2页 Laboratory Medicine and Clinic
关键词 新生儿ABO溶血病 母婴血型组合 血清学试验 ABO hemolytic disease of newborn maternal and neonatal blood type combination serological test
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