摘要
目的探讨中性粒细胞CD64指数在早期诊断脓毒症中的价值。方法采用前瞻性病例对照研究方法进行分析。选取117例重症监护室(ICU)住院患者,将其分为确诊脓毒症(42例)、临床脓毒症组(47例)和对照组(28例),各组患者均在入院24 h内采集静脉血样,应用流式细胞仪检测中性粒细胞CD64指数;同时检测外周血白细胞计数(WBC)及中性粒细胞比例(NE%)、超敏C反应蛋白(hs-CRP)和降钙素原(PCT)。结果流式细胞仪检测结果显示,与对照组比较,确诊脓毒症组和临床脓毒症组CD64指数、WBC、NE%、hs-CRP和PCT均显著增高(P<0.05);确诊脓毒症组CD64指数、WBC、NE%、hs-CRP和PCT均显著高于临床脓毒症组(P<0.05)。结论与WBC、NE%、hs-CRP和PCT均相比较,中性粒细胞CD64指数可作为早期诊断脓毒症的敏感指标,并可区分感染的严重程度,为临床正确治疗提供重要依据。
Objective To investigate the value of neutrophil CD64 index in the early diagnosis of sepsis. Methods The prospective case- control study method was used to analyze data. 117 patients were divided into the diagnosis of sepsis（ 42 cases）,sepsis group（ 47 cases） and control group（ 28 cases）. Venous blood samples were collected on admission 24 h,detection of neutrophil CD64 index by flow cytometry; at the same time,the peripheral white blood cell count（ WBC） and the percentage of neutrophils（ NE%）,High sensitivity C reactive protein（ hs- CRP） and procalcitonin（ PCT） were detected. Results Flow cytometry results showed that： compared with the control group,the clinical diagnosis of sepsis group and sepsis group,CD64 index,WBC,NE%,hs- CRP and PCT were significantly increased（ P〈0. 05）; diagnosis of sepsis group,CD64 index,WBC,NE%,hs- CRP and PCT were significantly higher than that of clinical sepsis disease group（ P〈0. 05）. Conclusion Compared with WBC,NE%,hs- CRP and PCT,neutrophil CD64 index can be used as a sensitive index in the early diagnosis of sepsis,severity and can distinguish infections,provide an important basis for correct clinical treatment.
出处
《宁夏医学杂志》
CAS
2015年第10期897-898,共2页
Ningxia Medical Journal
