摘要
目的探讨老年细菌性与病毒性上呼吸道感染(URTI)患者的血清降钙素原(PCT)、C-反应蛋白(CRP)、白介素-6(IL-6)水平表达差异。方法选择2019年6月至2020年6月厦门大学附属第一医院(我院)收治的45例老年细菌性URTI患者,纳入细菌感染组,选择同期于我院治疗的45例老年病毒性URTI患者,纳入病毒感染组。以咽拭子检测作为鉴别诊断“金标准”,所有患者均接受血清PCT、CRP、IL-6、白细胞计数(WBC)、中性粒细胞占比(N%)检测,并进行比较分析,绘制接受者操作特征曲线(ROC曲线)评价血清PCT、CRP、IL-6水平单独及联合检测对老年细菌性URTI的诊断价值。结果检测后,细菌感染组WBC、N%高于病毒感染组,差异有统计学意义(P<0.05);检测后,细菌感染组PCT、CRP、IL-6水平均高于病毒感染组,差异有统计学意义(P<0.05);经绘制受试者ROC曲线,结果显示,血清PCT、CRP、IL-6水平单独及联合诊断老年细菌性URTI的AUC分别为0.835、0.825、0.759、0.900,其中联合检测AUC面积最大,诊断价值高,且均高于PCT、CRP、IL-6单独诊断。结论血清PCT、CRP、IL-6水平对于老年细菌性URTI具有一定临床诊断价值,但三者联合诊断的诊断性能优于单独检测结果,可为临床后续治疗提供有效参考依据。
Objective To investigate the differences in the serum expression levels of procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)in elderly patients with bacterial and viral upper respiratory tract infections(URTI).Methods A total of 45 elderly patients with bacterial URTI admitted to the First Affiliated Hospital of Xiamen University(our hospital)from June 2019 to June 2020 were selected and included in the bacterial infection group.A total of 45 elderly patients with viral URTI who were treated in our hospital during the same period were selected and included in the viral infection group.The throat swab test was used as the"gold standard"for differential diagnosis.All patients received tests in serum PCT,CRP,IL-6,white blood cell count(WBC),and neutrophil percentage(N%),and the test results were compared and analyzed.The receiver operating characteristic curve(ROC curve)was drawn to evaluate the diagnostic value of single tests of serum PCT,CRP,and IL-6 levels alone and combination test in the diagnosis of elderly patients with bacterial URTI.Results After the test,the WBC and N%of the bacterial infection group were higher than those of the viral infection group,with statistically significant differences(P<0.05);after the test,the levels of PCT,CRP,and IL-6 in the bacterial infection group were higher than those in the viral infection group,with statistically significant differences(P<0.05).According to the drawn ROC curve of subjects,the single tests of serum PCT,CRP,and IL-6 levels alone and combination test showed the AUC for the diagnosis of elderly patients with bacterial URTI was 0.835,0.825,0.759 and 0.900,respectively.The combination test had the largest area of AUC and exerted higher diagnostic performance than that of single tests of PCT,CRP,and IL-6 alone.Conclusion Serum PCT,CRP,and IL-6 have certain clinical diagnostic value for elderly patients with bacterial URTI,but the combination diagnosis of the three shows better diagnostic performance than individual test results,which is helpful
作者
徐燕军
黄江山
陈智阳
XU Yanjun;HUANG Jiangshan;CHEN Zhiyang(Department of Laboratory Medicine,the First Affiliated Hospital of Xiamen University,Fujian,Xiamen 361000,China)
出处
《中国医药科学》
2022年第3期141-144,共4页
China Medicine And Pharmacy
关键词
上呼吸道感染
细菌感染
病毒感染
老年
降钙素原
C-反应蛋白
白介素-6
Upper respiratory tract infection
Bacterial infection
Viral infection
Elderly
Procalcitonin
C-reactive protein
Interleukin-6
