摘要
目的探讨滑膜基质金属蛋白酶3(MMP-3)对骨性关节炎患者病情的评估价值。方法选取2011年1月至2015年4月收治的骨性关节炎患者106例为骨性关节炎组,另选取滑膜皱襞综合征、单纯膝关节半月板损伤或者截肢的患者30例为对照组。Envision二步法检测滑膜MMP-3表达水平。结果骨性关节炎组与对照组MMP-3表达阳性细胞率分别为92.45%和20.00%,两组比较差异具有显著统计学意义(P<0.01);随着骨性关节炎患者病变程度升高,MMP-3表达水平逐渐升高,骨性关节炎患者病变程度与MMP-3表达水平呈正相关性(r=0.765,P=0.021)。结论 MMP-3在骨性关节炎患者滑膜中呈高表达水平,其表达水平与病变程度相关,可作为判断骨性关节炎病情的重要指标。
Objective To investigate the value of matrix metalloproteinases 3 （MMP-3） expression level in the evaluation of the grade of osteoarthritis. Methods One hundred and six patients with osteoarthritis in our hospi-tal from Jan. 2011 to Apr. 2015 were selected as osteoarthritis group, and another 30 patients with synovial plica syn-drome, knee meniscus injury and amputation were enrolled as control group. Envision two step method was used to de-termine the MMP-3 expression level at synovium. Results The positive MMP-3 expression rate of osteoarthritis group and control group were 92.45%and 20.00%, respectively, with significant difference between the two groups （P〈0.01）. With the increasing of grade of osteoarthritis, MMP-3 expression level significantly increased. Grade of os-teoarthritis was positively correlated with MMP-3 expression level （r=0.765, P=0.021）. Conclusion MMP-3 ex-pressed at high level at synovium in patients with osteoarthritis, and its expression level is positively correlated with grade of osteoarthritis.
出处
《海南医学》
CAS
2015年第20期2995-2997,共3页
Hainan Medical Journal
基金
沧州市科技支撑计划项目(编号:141302036)
