摘要
目的研究附桂骨痛胶囊(FGC)的抗炎镇痛作用。方法抗炎实验分别采用大鼠足跖肿胀法、小鼠腹腔毛细血管通透性法和小鼠棉球肉芽肿增生;镇痛实验采用甲醛致大鼠疼痛法、热板法和醋酸扭体法。结果FGC 60 mg.kg-1和200mg.kg-1能显著降低蛋清所致大鼠足跖肿胀百分率。FGC 100 mg.kg-1和300 mg.kg-1能有效抑制小鼠毛细血管通透性,提示该药有抗炎作用。镇痛实验中,FGC 20 mg.kg-1和60 mg.kg-1可明显减少甲醛致痛大鼠抬足次数,FGC 100mg.kg-1和300 mg.kg-1能明显提高热板致小鼠痛阈,减少扭体次数;FGC 300 mg.kg-1组还能显著延长扭体潜伏期。结论FGC有明显的抗炎、镇痛作用。
Objective To study the anti - inflammatory, and analgesic effect of FuguiGutong Capsule（FGC）. Methods Anti - inflammatory effect of FGC was studied with the model of egg white induced swelling in rat paw and of dye exudation induced by acetic acid. Using the pain model in mice induced by acetic and hot plate, the analgesic effect of FGC was investigated. Results FGC （60,200 mg · kg^-1 ）significantly reduced the degree of the swelling induced by egg white in rat, and FGC （ 100,300 mg · kg^-1 ） inhibited the dye exudation induced by acetic acid in mice, which indicated its anti -inflammatory its effect. FGC （20,600. mg · kg^-1 ） obviously decreased the number of rats, lifting paws. The number of writhe induced by acetic acid decreased significanhy and the pain threshold of temperature stimuli increased markedly in mice when administrated with FGC （100,300 mg·kg^-1）： FGC （300 mg· kg^-1 ） also prolonged the latency of writhe. Conclusion FGC has obvious anti - inflammatory and analygesic effects.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2007年第5期F0003-F0004,共2页
Lishizhen Medicine and Materia Medica Research
关键词
附桂骨痛胶囊
抗炎
镇痛
FuguiGutong Capsule
Anti - inflammatlry
Analgesic
