摘要
目的探讨基质金属蛋白酶(MMP-7、MMP-9)及金属蛋白酶组织抑制物(TIMP-3)在骨性关节炎患者膝关节滑膜中的表达和意义。方法对40例膝关节滑膜标本应用SABC免疫组化法显色MMP-7、MMP-9及TIMP-3在病变组和正常组的表达,并用HE染色观察细胞形态。结果MMP-7、MMP-9及TIMP-3的表达在正常关节滑膜与重度骨性关节炎患者膝关节滑膜中的表达有显著差异(P<0.05)。结论MMP-7、MMP-9及TIMP-3的表达是骨性关节炎重要的标志性诊断指标。
Objective To investigate the expression and significance of matrix metalloproteinase-7(MMP-7),matrix metalloproteinase-9(MMP-9),and tissue inhibitor of matrix metalloproteinase-3(TIMP-3)in osteoarthritis patients synovium of knee joint.Methods The histological changes of synovium of knee joint was examined by hematoxyllin-eosin staining and immunohistochemical expression of MMP-7,MMP-9,TIMP-3 in osteoarthritis in 20 osteoarthritis cases and 20 normal controls.All data were statistically analyzed by χ2 test...
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2009年第4期284-285,共2页
Journal of China Medical University
基金
辽宁省科学技术计划项目(2008228009-14)
