摘要
目的:探讨食管癌中microRNA-21(miR-21)表达水平与放疗敏感性和预后的关系。方法:收集在我院接受放疗的食管癌患者60例,采用RT-PCR方法检测miR-21的相对表达量,并分析其与临床病理特征、放疗疗效和预后的相关性。结果:miR-21的表达水平与肿瘤大小、淋巴结和远处转移明显相关(P<0.05)。在60例食管癌患者中,CR、PR和NC组患者中miR-21的表达水平分别为1.56±0.35、2.82±0.84和3.31±1.32,miR-21的表达水平与食管癌的放疗敏感性呈负相关(P<0.05)。Kaplan-Meier分析显示miR-21低表达组放疗后的生存时间明显高于高表达组,差异有显著统计学意义(P<0.05)。结论:肿瘤组织中miR-21表达量可作为评价食管癌放疗敏感性和预后的预测指标。
Objective： To investigate the expression of microRNA-21（ miR-21） in patients with esophageal cancer and to analyze the association of the expression with radiosensitivity and prognosis. Methods： The expression levels of miR-21 in 60 tumor tissues of esophageal cancer were detected by using RT-PCR. The correlations between the expression of miR-21 and pathological characteristics,radiosensitivity and prognosis were analyzed. Results： The expression of miR-21 was associated with tumor length,lymphatic metastasis and distant metastases（ P 0. 05）. The expression of miR-21 in CR,PR and CN groups were 1. 56 ± 0. 35,2. 82 ± 0. 84 and 3. 31 ± 1. 32,respectively. The expression of miR-21 has negative correlation with radiosensitivity of esophageal cancer. Low expression of miR-21 was significantly correlated with overall survival of esophageal cancer（ P 0. 05）. Conclusion： The evaluation of miR-21 would be useful not only for assessment prognosis but also for monitoring radiosensitivity in esophageal cancer.
出处
《现代肿瘤医学》
CAS
2015年第22期3259-3261,共3页
Journal of Modern Oncology
