摘要
食管癌是我国常见的消化系统恶性肿瘤之一。食管癌具体发病机制尚不清楚。microRNA是一类内源性非编码蛋白短链RNA,参与调控细胞增殖、分化、凋亡、耐药和侵袭转移等多种生物学行为。其中miR-21最受关注。miR-21在食管癌细胞或组织中高表达,发挥着类似于癌基因的作用。miR-21通过对靶基因的调控,参与食管癌细胞增殖、凋亡、侵袭、耐药和转移等过程。通过抑制miR-21的表达或阻碍miR-21与靶基因的相互作用在食管癌治疗中具有良好的应用前景。本文就miR-21在食管癌中的研究进展进行综述。
Esophageal cancer is one of the most common digestive system neoplasms in China. The mechanism of esophageal cancer is still unclear, microRNA is a kind of endogenous non-coding short RNA, which regulates many tu- mor biological behaviors,such as cell multiplication, differentiation, apoptosis, drug resistance and invasion, miR-21 is valued highly in miRNA. It express highly in esophageal cancer cell and tissue, miR-21 participates in esophageal cancer cell multiplication, differentiation, apoptosis, drug resistance and metastasis via regulating gene expression. This review summarizes the advances in research on miR-21 in esophageal cancer .
作者
杨鲸蓉
吴波
YANG Jingrong WU Bo(Department of Thoracic and Cardiovascular Surgery, Fuzhou General Hospital of Nanjing Military Command, Fujian Province, Fuzhou 350025, China Department of Emergency, Fuzhou General Hospital of Nanjing Military Com- mand, Fujian Province, Fuzhou 350025, China)
出处
《中国医药导报》
CAS
2017年第16期40-43,共4页
China Medical Herald
基金
福建省自然科学基金资助项目(2017J01320)
