摘要
目的探讨高通量血液透析（Hf-HD）对尿毒症患者失眠程度和生活质量的影响。方法选取2012年8月~2014年11月在本院行血液透析的120例尿毒症患者作为研究对象,随机分为Hf-HD组（n=61）和低通量血液透析（Lf-HD）组（n=59）。治疗12周后,通过对其失眠严重程度指数（ISI）、肾脏病生存质量量表（KDQOL-SFTM）相关指标变化的分析,比较两组治疗前后失眠严重程度及生活质量的变化。结果 Hf-HD组治疗后的ISI总分显著低于Lf-HD组,差异有统计学意义（P〈0.05）。Hf-HD组的肾病症状、认知功能、睡眠、患者满意度得分显著高于Lf-HD组,差异有统计学意义（P〈0.05）。Hf-HD组的躯体疼痛项得分显著高于Lf-HD组,差异有统计学意义（P〈0.01）。Hf-HD组的生理机能、生理功能、精神健康得分高于Lf-HD组,差异有统计学意义（P〈0.05）。结论 HfHD通过对较大分子尿毒症毒素的清除,能够有效改善血液透析患者的睡眠质量和相关生活质量。
Objective To explore the influence of high flux hemodialysis（Hf-HD） on sleeplessness degree and life quality of uremic patient. Methods 120 uremic patients conducted hemodialysis from August 2012 to November 2014 in our hospital were selected and randomly divided into the Hf-HD group（n=61） and the low flux hemodialysis（Lf-HD）group（n=59）.After treatment for 12 weeks,the change of sleeplessness degree and life quality were compared before and after treatment in two groups by analysis of the index change of insomnia severity index（ISI） and kidney disease quality of life sorth form（KDQOL-SFTM）. Results The total score of ISI in the Hf-HD group was lower than that in the Lf-HD group,with significant difference（P0.05）.The score of nephropathy symptoms,cognitive function,sleeping and patient satisfaction in the Hf-HD group was higher than that in the Lf-HD group,with significant difference（P0.05）.The score of body pain in the Hf-HD group was higher than that in the Lf-HD group,with significant difference（P0.01）.The score of physiological enginery,physiological function and mental health in the Hf-HD group was higher than that in the Lf-HD group,with significant difference（P0.05）. Conclusion Hf-HD by removal large molecule uremic toxin can effective improve the sleeping quality and related life quality of hemodialysis patients.
出处
《中国当代医药》
2015年第28期60-62,65,共4页
China Modern Medicine
基金
山东省潍坊市科学技术发展计划项目(20112079)
关键词
高通量血液透析
尿毒症患者
失眠程度
High flux hemodialysis
Uremic patients
Sleeplessness degree
