摘要
目的评价癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、糖类抗原CA-125、CA-242、神经原特异性烯醇化酶(NSE)五种肿瘤标志物在肺癌早期诊断中的临床价值。方法回顾性分析708例住院病人5项血清肿瘤标志物水平和临床病理资料。结果肺癌5种血清肿瘤标志物阳性检出率明显高于与肺良性疾病,差异有统计学意义(P<0.05);鳞癌、腺癌、小细胞癌阳性检出率分别是CYFRA21-1、(CEA、CA-242)、NSE最高,相比其他标志物均有统计学意义(P<0.05)。腺癌CEA、CA-125、CA-242肿瘤标志物水平明显高于鳞癌、小细胞肺癌(P<0.05),鳞癌CYFRA21-1水平明显高于腺癌、小细胞肺癌(P<0.05);小细胞肺癌NSE水平明显高于腺癌、鳞癌(P<0.05)。肿瘤标志物水平与肺癌临床分期相关,标志物水平越高,分期越晚。结论 CEA、CYFRA21-1、CA-125、CA-242及NSE仍是诊断肺癌的重要肿瘤标志物,鳞癌、腺癌、小细胞肺癌的实验室诊断可分别优先选择CYFRA21-1,CEA、CA-242,NSE。
Objective To evaluate the clinical value of 19 tumor markers in the early diagnosis of lung cancer by evaluating the five kinds of tumor markers（CEA）,CYFRA21-1,CA-125 ,CA-242 and NSE. Methods Retrospective analysis of 708 cases of hospitalized patients with 5 serum tumor markers level and clinical pathology data.Results The positive detection rate of 5 serum tumor markers in lung cancer was significantly higher than that in benign lung disease （P〈0.05）. The positive rate of squamous cell carcinoma, adenocarcinoma, small cell carcinoma was CYFRA21-1, （CEA,CA-242）and NSE was the highest, compared with other markers（P〈0.05）. The levels of CEA, CA-125 and CA-242 were significantly higher than those of squamous cell carcinoma and small cell lung cancer （P〈0.05）, and the level of CYFRA21-1 was significantly higher than that of ade-nocarcinoma and small cell lung cancer （P〈0.05）. The level of NSE in small cell lung cancer was significantly higher than that of adenocarcinoma and squamous cell carcinoma （P〈0.05）. Tumor markers were associated with clinical stages of lung cancer, and the higher the level of markers, the later stage of staging.Conclusions CEA,CYFRA21-1,CA-242,NSE and CA-125 were still im-portant tumor markers in diagnosis of lung cancer, the laboratory diagnosis of squamous cell car-cinoma, adenocarcinoma, small cell lung cancer, CYFRA21-1,CEA,CA-242,NSE.
出处
《现代诊断与治疗》
CAS
2015年第17期3841-3843,共3页
Modern Diagnosis and Treatment
关键词
肺癌
肿瘤标志物
早期诊断
Lung cancers
Tumor markers
Early diagnosis
