摘要
目的:分析神经元特异性烯醇化酶与新生儿缺氧缺血性脑病临床分度及脑性瘫痪发生的相关性。方法:选择2001-07/2003-07在珠海市人民医院新生儿室住院的110例足月缺氧缺血性脑病患儿。①根据新生儿缺氧缺血性脑病诊断依据和临床分度标准分为3组,轻度组(n=65)、中度组(n=35)、重度组(n=10);选择同期出生足月正常新生儿20例为对照组。用ELISA法测定缺氧缺血性脑病各组患儿血中神经元特异性烯醇化酶的含量并进行比较。②将所有观察患儿均按照新生儿缺氧缺血性脑病的治疗方案进行后续治疗,随机分为3组进行早期干预,干预1组干预时间为满1个月起至24个月;干预2组为满6个月起至24个月岁;干预3组为满12个月岁起至24个月。干预方法采用鲍秀兰教授0～3岁潜能开发指南进行。随访时间为6个月以内每月1次,6个月～12个月每2个月1次,12个月～24个月每3～6个月1次;随诊内容除一般的健康体检外,重点检查有否脑性瘫痪症状,并指导早期干预。对照组及各随访非干预时间按传统喂养和照料。经统计学处理分析神经元特异性烯醇化酶与缺氧缺血性脑病严重程度、脑性瘫痪的相关性。结果:110例缺氧缺血性脑病患儿和20例正常新生儿,均进入结果分析。①轻度缺氧缺血性脑病组血清神经元特异性烯醇化酶与对照组接近,差异无显著性意义[(12.36±4.55),(8.32±2.89)μg/L,P>0.05];中度、重度缺氧缺血性脑病血清神经元特异性烯醇化酶与对照组比较明显升高,差异有显著性意义[(35.45±13.56),(69.98±19.92)μg/L,t=9.354,16.452,P<0.01],缺氧缺血性脑病临床分型与神经元特异性烯醇化酶成正相关(r=0.754,P<0.001)。有过脑性瘫痪早期症状患儿的血清神经元特异性烯醇化酶含量显著高于无脑性瘫痪早期症状患儿,差异有显著性意义[(33.26±20.33),(18.34±9.87)μg/L,t=6.98,P<0.01]。②随访结果:轻度缺氧缺血性脑病�
AIM： To analyze the correlation of neuron-specific enolase （NSE） with incidence of cerebral palsy and clinical grading of newborns with hypoxicischemic encephalopathy （HIE）.
METHODS： 110 full-term newborns with HIE, who were admitted in newborn room of Zhuhai People＇s Hospital from July 2001 to July 2003, were selected. ①They were divided into mild group （n=65）, moderate group （n=35）, severe group （n=10）, based on clinical diagnostic evidence and clinical grading： for newborns with HIE. 20 normal newborns who wereborn in the same period were selected as control group. The blood NSEs of each group of patients with HIE were determined by ELISA and then compared. ②All the patients were treated according to treatment regimen for HIE, who underwent early intervention by being divided into 3 groups randomly, with the intervention time being from 1 month old to 24 months old, 6 months old to 24 months old, 12 months to 24 months old for group 1, group 2 and group 3, respectively, by adopting the guideline for developing potential of 0-3 year-old children designed by Professor Bao. Those who were under 6 months old were followed-up monthly, for 6 months old to 12 months old bimonthly, for 12 months old to 24 months old just once every 3-6 months, with general physical chack-up being included, cerebral palsy being focused on, and instruction being given on early intervention. Those in the control group was fed and looked after in traditional way, so dose those in the non follow-up period. Finally the correlation of NSE with severity of HIE and cerebral palsy was analyzed after statistical analysis.
RESULTS： Totally 110 children with HIE and 20 normal newborns were involved in the result analysis. ①There was no significant difference in NSEs between mild group and control group [（1236±4.55）, （832±9.89）μg/L, P 〉 0.05]; whereas NSEs in moderate and severe groups were markedly higher than that in the control group, which had significant differences [（35.45±13.56）, （6
出处
《中国临床康复》
CSCD
北大核心
2006年第18期97-100,共4页
Chinese Journal of Clinical Rehabilitation
